Entity Details

Primary name DREB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16643
EntryNameDREB_HUMAN
FullNameDrebrin
TaxID9606
Evidenceevidence at protein level
Length649
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDBN1

GO terms

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GOName
GO:0001701 in utero embryonic development
GO:0003779 actin binding
GO:0005522 profilin binding
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005921 gap junction
GO:0007015 actin filament organization
GO:0010643 cell communication by chemical coupling
GO:0010644 cell communication by electrical coupling
GO:0014069 postsynaptic density
GO:0015629 actin cytoskeleton
GO:0030027 lamellipodium
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030427 site of polarized growth
GO:0030833 regulation of actin filament polymerization
GO:0030863 cortical cytoskeleton
GO:0030864 cortical actin cytoskeleton
GO:0031915 positive regulation of synaptic plasticity
GO:0032507 maintenance of protein location in cell
GO:0042641 actomyosin
GO:0045211 postsynaptic membrane
GO:0045296 cadherin binding
GO:0045773 positive regulation of axon extension
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048812 neuron projection morphogenesis
GO:0050773 regulation of dendrite development
GO:0051015 actin filament binding
GO:0051220 cytoplasmic sequestering of protein
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0061351 neural precursor cell proliferation
GO:0098974 postsynaptic actin cytoskeleton organization
GO:0098978 glutamatergic synapse
GO:0099524 postsynaptic cytosol
GO:1902685 positive regulation of receptor localization to synapse

Subcellular Location

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Subcellular Location
Cell junction
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR002108 Actin-depolymerising factor homology domainDomainDomain
IPR028438 DrebrinFamilyFamily
IPR029006 ADF-H/Gelsolin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
104300 OMIMAlzheimer disease (AD)Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituents of these plaques are neurotoxic amyloid-beta protein 40 and amyloid-beta protein 42, that are produced by the proteolysis of the transmembrane APP protein. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products, such as C31, are also implicated in neuronal death. The protein represented in this entry may be involved in disease pathogenesis. In brains of patients with AD, decreased expression and absence from dystrophic neurites in amyloid plaques. Disappearance of debrin from the hippocampus may contribute to the pathogenesis of memory disturbance in AD.

Interactions

44 interactions

InteractorPartnerSourcesPublicationsLink
DREB_HUMANGRB2_HUMANBioGRID, IntAct12577067 25814554 details
DREB_HUMANZN598_HUMANHPRD, IntAct16169070 details
DREB_HUMANSPT5H_HUMANHPRD, IntAct16169070 details
DREB_HUMANNIPBL_HUMANHPRD, IntAct16169070 details
DREB_HUMANESR1_HUMANBioGRID, IntAct20348541 21182205 details
DREB_HUMANBAK_HUMANBioGRID, MINT21900206 details
DREB_HUMANFBW1A_HUMANBioGRID, MINT21900206 details
DREB_HUMANCDKA2_HUMANBioGRID, MINT21900206 details
DREB_HUMANDUS23_HUMANBioGRID, MINT21900206 details
DREB_HUMANFHL1_HUMANBioGRID, MINT21900206 details
DREB_HUMANMLP3B_HUMANBioGRID, MINT21900206 details
DREB_HUMANTAB1_HUMANBioGRID, MINT21900206 details
DREB_HUMANMK06_HUMANBioGRID, MINT21900206 details
DREB_HUMANMEST_HUMANBioGRID, MINT21900206 details
DREB_HUMANCPSF5_HUMANBioGRID, MINT21900206 details
DREB_HUMANNUDT3_HUMANBioGRID, MINT21900206 details
DREB_HUMANSPN1_HUMANBioGRID, MINT21900206 details
DREB_HUMANTCTP_HUMANBioGRID, MINT21900206 details
DREB_HUMANUB2D3_HUMANBioGRID, MINT21900206 details
DREB_HUMANPTEN_HUMANBioGRID, IntAct23940795 26561776 details
DREB_HUMANRBG10_HUMANBioGRID, IntAct25814554 details
DREB_HUMANRBG1L_HUMANBioGRID, IntAct25814554 details
DREB_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
DREB_HUMANTINF2_HUMANbhf-ucl, BioGRID21044950 details
DREB_HUMANACD_HUMANbhf-ucl, BioGRID21044950 details
DREB_HUMANPOTE1_HUMANbhf-ucl, BioGRID21044950 details
DREB_HUMANPKCB1_HUMANUniProt28966017 details
DREB_HUMANOGT1_HUMANBioGRID32994395 details
DREB_HUMANNEMO_HUMANIntAct14743216 details
DREB_HUMANM3K3_HUMANIntAct14743216 details
DREB_HUMANRIPK3_HUMANIntAct14743216 details
DREB_HUMANAFAD_HUMANIntAct23750010 details
DREB_HUMANNECT2_HUMANIntAct23750010 details
DREB_HUMANNECT3_HUMANIntAct23750010 details
DREB_HUMANDREB_HUMANIntAct23750010 23979715 details
DREB_HUMANCXCR4_HUMANIntAct20215400 23926103 details
DREB_HUMANGRN_HUMANIntAct25839164 details
DREB_HUMANHOME2_HUMANBioGRID, HPRD, IntAct12676529 28514442 details
DREB_HUMANDNMBP_HUMANBioGRID, HPRD14506234 details
DREB_HUMANUB2Q2_HUMANBioGRID16300736 details
DREB_HUMANPHB_HUMANBioGRID19725029 details
DREB_HUMANPK3C3_HUMANBioGRID23569248 details
DREB_HUMANRN168_HUMANBioGRID27558965 details
DREB_HUMANPROF1_HUMANHPRD9473484 details