Entity Details

Primary name PTPRO_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16827
EntryNamePTPRO_HUMAN
FullNameReceptor-type tyrosine-protein phosphatase O
TaxID9606
Evidenceevidence at protein level
Length1216
SequenceStatuscomplete
DateCreated2003-07-19
DateModified2021-06-02

Ontological Relatives

GenesPTPRO

GO terms

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GOName
GO:0000902 cell morphogenesis
GO:0002548 monocyte chemotaxis
GO:0003093 regulation of glomerular filtration
GO:0003105 negative regulation of glomerular filtration
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006470 protein dephosphorylation
GO:0007411 axon guidance
GO:0010812 negative regulation of cell-substrate adhesion
GO:0010977 negative regulation of neuron projection development
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0016791 phosphatase activity
GO:0017147 Wnt-protein binding
GO:0030027 lamellipodium
GO:0030032 lamellipodium assembly
GO:0030424 axon
GO:0030426 growth cone
GO:0032835 glomerulus development
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0036060 slit diaphragm assembly
GO:0042803 protein homodimerization activity
GO:0043005 neuron projection
GO:0043197 dendritic spine
GO:0045296 cadherin binding
GO:0070062 extracellular exosome
GO:0072112 glomerular visceral epithelial cell differentiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090260 negative regulation of retinal ganglion cell axon guidance
GO:0098978 glutamatergic synapse
GO:0098982 GABA-ergic synapse
GO:1990264 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000242 PTP type protein phosphataseDomainDomain
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR003595 Protein-tyrosine phosphatase, catalyticDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR042996 Receptor-type tyrosine-protein phosphatase OFamilyFamily

Diseases

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Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
PTPRO_HUMANPTPRO_HUMANBioGRID, MINT15978577 27432908 details
PTPRO_HUMANACTG_HUMANHPRD, IntAct16169070 details
PTPRO_HUMANCADH2_HUMANIntAct19167335 details
PTPRO_HUMANTEC_HUMANIntAct19167335 details
PTPRO_HUMANERBB2_HUMANIntAct19167335 details
PTPRO_HUMANPGFRB_HUMANIntAct19167335 details
PTPRO_HUMANMET_HUMANBioGRID, IntAct19167335 28330616 details
PTPRO_HUMANPAXI_HUMANIntAct19167335 details
PTPRO_HUMANLCK_HUMANIntAct19167335 details
PTPRO_HUMANCTNB1_HUMANIntAct19167335 details
PTPRO_HUMANINSR_HUMANIntAct19167335 details
PTPRO_HUMANCSK_HUMANIntAct19167335 details
PTPRO_HUMANGAB1_HUMANIntAct19167335 details
PTPRO_HUMANNTRK1_HUMANIntAct19167335 details
PTPRO_HUMANPDPK1_HUMANIntAct19167335 details
PTPRO_HUMANNSF_HUMANIntAct19167335 details
PTPRO_HUMANEPOR_HUMANIntAct19167335 details
PTPRO_HUMANMK03_HUMANIntAct19167335 details
PTPRO_HUMANTIE2_HUMANIntAct19167335 details
PTPRO_HUMANWASP_HUMANIntAct19167335 details
PTPRO_HUMANCBL_HUMANIntAct19167335 details
PTPRO_HUMANDPPA4_HUMANBioGRID, MINT21900206 details
PTPRO_HUMANDPYL4_HUMANBioGRID, MINT21900206 details
PTPRO_HUMANSH3G1_HUMANBioGRID, MINT21900206 details
PTPRO_HUMANSH3G3_HUMANBioGRID, MINT21900206 details
PTPRO_HUMAN1433Z_HUMANBioGRID, MINT21900206 details
PTPRO_HUMANA4_HUMANBioGRID21832049 details
PTPRO_HUMANUFL1_HUMANBioGRID32545848 details
PTPRO_HUMANKIT_HUMANBioGRID, HPRD10397721 details
PTPRO_HUMANTERA_HUMANBioGRID23533167 28675297 details
PTPRO_HUMANVILI_HUMANBioGRID23533167 details
PTPRO_HUMANSPTA1_HUMANBioGRID23533167 details
PTPRO_HUMANKSYK_HUMANBioGRID23533167 details
PTPRO_HUMANPIM1_HUMANHPRD11368509 details