Entity Details

Primary name DUS6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16828
EntryNameDUS6_HUMAN
FullNameDual specificity protein phosphatase 6
TaxID9606
Evidenceevidence at protein level
Length381
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDUSP6

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0000188 obsolete inactivation of MAPK activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006470 protein dephosphorylation
GO:0008330 protein tyrosine/threonine phosphatase activity
GO:0014070 response to organic cyclic compound
GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity
GO:0030154 cell differentiation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035970 peptidyl-threonine dephosphorylation
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0051019 mitogen-activated protein kinase binding
GO:0051409 response to nitrosative stress
GO:0060420 regulation of heart growth
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070848 response to growth factor
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR001763 Rhodanese-like domainDomainDomain
IPR008343 Mitogen-activated protein (MAP) kinase phosphataseFamilyFamily
IPR020422 Dual specificity protein phosphatase domainDomainDomain
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR036873 Rhodanese-like domain superfamilyFamilyHomologous superfamily

Diseases

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