Entity Details

Primary name MAP2K5
Entity type gene
Source Source Link

Details

PrimaryID5607
RefseqGeneNG_029143
SymbolMAP2K5
Namemitogen-activated protein kinase kinase 5
Chromosome15
Location15q23
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-14
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsMP2K5_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000187 obsolete activation of MAPK activity
GO:0004672 protein kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005819 spindle
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0007507 heart development
GO:0030307 positive regulation of cell growth
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032717 negative regulation of interleukin-8 production
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051247 positive regulation of protein metabolic process
GO:0060761 negative regulation of response to cytokine stimulus
GO:0070375 ERK5 cascade
GO:0071363 cellular response to growth factor stimulus
GO:0071499 cellular response to laminar fluid shear stress
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Diseases

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Interactions

94 interactions

InteractorPartnerSourcesPublicationsLink
MAP2K5MAP3K3BioGRID, IntAct11073940 12813044 14743216 16861740 19903815 24975362 25241761 28514442 details
MAP2K5MAPK7BioGRID, IntAct24975362 28514442 32296183 7759517 details
MAP2K5GRB2IntAct17474147 details
MAP2K5CDC42BPBBioGRID, IntAct20936779 details
MAP2K5YWHAZBioGRID, IntAct20936779 details
MAP2K5LNX2BioGRID, IntAct, MINT21516116 29892012 31515488 details
MAP2K5XRCC6BioGRID, IntAct21988832 details
MAP2K5RPL28BioGRID, IntAct21988832 details
MAP2K5MAP3K2BioGRID, IntAct11073940 19903815 21988832 24975362 28514442 31980649 details
MAP2K5ESRRABioGRID, IntAct21988832 details
MAP2K5ASRGL1BioGRID, MINT21900206 details
MAP2K5STAMBPBioGRID, IntAct16730941 details
MAP2K5ZNF426BioGRID, IntAct32296183 details
MAP2K5SQSTM1BioGRID, IntAct12813044 19903815 31980649 32296183 34079125 details
MAP2K5GUCD1BioGRID, IntAct32296183 details
MAP2K5DUSP21BioGRID, IntAct32296183 details
MAP2K5ZNF620BioGRID, IntAct32296183 details
MAP2K5PFDN5BioGRID, IntAct32296183 details
MAP2K5PRKCZBioGRID11158308 details
MAP2K5MAP2K5BioGRID28205554 31980649 7759517 details
MAP2K5PARD6ABioGRID12813044 details
MAP2K5AKT1BioGRID28205554 details
MAP2K5CCND2BioGRID28205554 details
MAP2K5CD44BioGRID28205554 details
MAP2K5CDK4BioGRID28205554 details
MAP2K5CDK6BioGRID28205554 details
MAP2K5CDKN2ABioGRID28205554 details
MAP2K5CDKN2BBioGRID28205554 details
MAP2K5EPHA2BioGRID28205554 details
MAP2K5ERBB2BioGRID28205554 details
MAP2K5FGFR4BioGRID28205554 details
MAP2K5GLIS2BioGRID28205554 details
MAP2K5GRM1BioGRID28205554 details
MAP2K5HGFBioGRID28205554 details
MAP2K5LATS2BioGRID28205554 details
MAP2K5MAP2K3BioGRID28205554 details
MAP2K5METBioGRID28205554 details
MAP2K5MYCBioGRID28205554 details
MAP2K5NF2BioGRID28205554 details
MAP2K5PDGFRABioGRID28205554 details
MAP2K5RAF1BioGRID28205554 details
MAP2K5STK11BioGRID28205554 details
MAP2K5TEAD2BioGRID28205554 details
MAP2K5MAP2K6BioGRID28205554 details
MAP2K5ARAFBioGRID28205554 details
MAP2K5ARNTBioGRID28205554 details
MAP2K5BECN1BioGRID28205554 details
MAP2K5CDKN2CBioGRID28205554 details
MAP2K5FZR1BioGRID28205554 details
MAP2K5HIF1ABioGRID28205554 details
MAP2K5MDM4BioGRID28205554 details
MAP2K5TERTBioGRID28205554 details
MAP2K5TP53BioGRID28205554 details
MAP2K5TSC1BioGRID28205554 details
MAP2K5GSK3BIntAct17353931 details
MAP2K5HSP90AB1BioGRID, IntAct22939624 31980649 details
MAP2K5HSP90AA1BioGRID, IntAct22939624 31980649 details
MAP2K5ENO1BioGRID15805119 details
MAP2K5PRKCIBioGRID12813044 details
MAP2K5GCH1BioGRID19294699 details
MAP2K5SIRT3IntAct19343720 details
MAP2K5C10orf88BioGRID, IntAct28514442 details
MAP2K5TRAF7BioGRID, IntAct28514442 details
MAP2K5CDC37BioGRID, IntAct28514442 31980649 details
MAP2K5VIMBioGRID, IntAct30021884 details
MAP2K5DNAJA2BioGRID, IntAct31980649 details
MAP2K5BAG2BioGRID, IntAct31980649 details
MAP2K5HSPB1BioGRID, IntAct31980649 details
MAP2K5TUBBBioGRID, IntAct31980649 details
MAP2K5HSPA8BioGRID, IntAct31980649 details
MAP2K5HSPA6BioGRID, IntAct31980649 details
MAP2K5TCP1BioGRID, IntAct31980649 details
MAP2K5ATP5F1ABioGRID, IntAct31980649 details
MAP2K5DNAJA1BioGRID, IntAct31980649 details
MAP2K5CCT6ABioGRID, IntAct31980649 details
MAP2K5CCT5BioGRID, IntAct31980649 details
MAP2K5CCT3BioGRID, IntAct31980649 details
MAP2K5EMDBioGRID, IntAct31980649 details
MAP2K5CCT8BioGRID, IntAct31980649 details
MAP2K5CCT4BioGRID, IntAct31980649 details
MAP2K5TUBB4BBioGRID, IntAct31980649 details
MAP2K5CCT2BioGRID, IntAct31980649 details
MAP2K5SLC25A3BioGRID, IntAct31980649 details
MAP2K5SLC25A11BioGRID, IntAct31980649 details
MAP2K5RPL22L1BioGRID, IntAct31980649 details
MAP2K5CCT7BioGRID, IntAct31980649 details
MAP2K5SLC25A22BioGRID, IntAct31980649 details
MAP2K5SLC25A18BioGRID, IntAct31980649 details
MAP2K5MAGEB2BioGRID, IntAct31980649 details
MAP2K5TUBA1BBioGRID, IntAct31980649 details
MAP2K5TUBA4ABioGRID, IntAct31980649 details
MAP2K5HSPA1ABioGRID, IntAct31980649 details
MAP2K5HSPA1BIntAct31980649 details
MAP2K5NXF1BioGRID22658674 details