Entity Details

Primary name PTGS2
Entity type gene
Source Source Link

Details

PrimaryID5743
RefseqGeneNG_028206
SymbolPTGS2
Nameprostaglandin-endoperoxide synthase 2
Chromosome1
Location1q31.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsPGH2_HUMAN

GO terms

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GOName
GO:0001516 prostaglandin biosynthetic process
GO:0004601 peroxidase activity
GO:0004666 prostaglandin-endoperoxide synthase activity
GO:0005637 nuclear inner membrane
GO:0005640 nuclear outer membrane
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0006954 inflammatory response
GO:0006979 response to oxidative stress
GO:0008217 regulation of blood pressure
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0019221 cytokine-mediated signaling pathway
GO:0019371 cyclooxygenase pathway
GO:0019372 lipoxygenase pathway
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0031622 positive regulation of fever generation
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0042759 long-chain fatty acid biosynthetic process
GO:0043005 neuron projection
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0046872 metal ion binding
GO:0050727 regulation of inflammatory response
GO:0051213 dioxygenase activity
GO:0071456 cellular response to hypoxia
GO:0071636 positive regulation of transforming growth factor beta production
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090271 positive regulation of fibroblast growth factor production
GO:0090336 positive regulation of brown fat cell differentiation
GO:0090362 positive regulation of platelet-derived growth factor production
GO:0150077 regulation of neuroinflammatory response

Diseases

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Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
PTGS2CASKBioGRID, IntAct24722188 details
PTGS2PTGS2BioGRID, DIP, HPRD14667819 16606823 21467029 23955344 27226593 details
PTGS2TP53BioGRID, HPRD11687965 15707991 16928824 19465063 21187340 21763744 details
PTGS2CAV1BioGRID, HPRD11432874 19960513 24089527 details
PTGS2COPS5BioGRID17429597 details
PTGS2COPS7ABioGRID17429597 details
PTGS2PTGISBioGRID21035466 details
PTGS2NUCB1BioGRID, HPRD18493301 8643612 details
PTGS2USP22BioGRID25817787 details
PTGS2ABHD16AHPRD14667819 details
PTGS2SUMO1BioGRID, IntAct18820298 21187340 details
PTGS2COPS3BioGRID17429597 details
PTGS2CUL1BioGRID17429597 details
PTGS2CUL4ABioGRID17429597 details
PTGS2RBX1BioGRID17429597 details
PTGS2PSMD1BioGRID17429597 details
PTGS2PSMC5BioGRID17429597 details
PTGS2DERL1BioGRID24089527 details
PTGS2SELENOSBioGRID24089527 details
PTGS2VCPBioGRID24089527 details
PTGS2ELMO1BioGRID20732417 details
PTGS2PTGS1BioGRID18838483 details
PTGS2EP300BioGRID16928824 21187340 details
PTGS2MAPK3BioGRID21187340 details
PTGS2APPBioGRID14724276 details
PTGS2AGTR1BioGRID25231994 details
PTGS2PTGER1BioGRID24614038 details
PTGS2LRRK2IntAct24725412 details
PTGS2LMAN2LBioGRID, IntAct28514442 details
PTGS2HLA-ABioGRID, IntAct30021884 details
PTGS2FAF2BioGRID26389662 details
PTGS2TP53BP1BioGRID29656893 details
PTGS2ERBB2IntAct15380516 details
PTGS2CEBPDIntAct18820298 details
PTGS2CEBPBIntAct18820298 details
PTGS2HDAC4IntAct18820298 details
PTGS2HDAC1IntAct18820298 details
PTGS2ELAVL1BioGRID17383427 22544606 details
PTGS2CTNNB1BioGRID22544606 details
PTGS2CELF2BioGRID17383427 details
PTGS2HSPA4BioGRID23109422 details
PTGS2HNRNPDBioGRID23109422 details