Entity Details

Primary name BMP4
Entity type gene
Source Source Link

Details

PrimaryID652
RefseqGeneNG_009215
SymbolBMP4
Namebone morphogenetic protein 4
Chromosome14
Location14q22.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-12-11
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsBMP4_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000186 obsolete activation of MAPKK activity
GO:0001649 osteoblast differentiation
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001843 neural tube closure
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001958 endochondral ossification
GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0002062 chondrocyte differentiation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002320 lymphoid progenitor cell differentiation
GO:0003014 renal system process
GO:0003130 BMP signaling pathway involved in heart induction
GO:0003139 secondary heart field specification
GO:0003148 outflow tract septum morphogenesis
GO:0003149 membranous septum morphogenesis
GO:0003163 sinoatrial node development
GO:0003180 aortic valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003197 endocardial cushion development
GO:0003279 cardiac septum development
GO:0003323 type B pancreatic cell development
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0007182 common-partner SMAD protein phosphorylation
GO:0007281 germ cell development
GO:0007492 endoderm development
GO:0007500 mesodermal cell fate determination
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009791 post-embryonic development
GO:0009948 anterior/posterior axis specification
GO:0010159 specification of animal organ position
GO:0010453 regulation of cell fate commitment
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010942 positive regulation of cell death
GO:0021537 telencephalon development
GO:0021904 dorsal/ventral neural tube patterning
GO:0021978 telencephalon regionalization
GO:0021983 pituitary gland development
GO:0030218 erythrocyte differentiation
GO:0030224 monocyte differentiation
GO:0030225 macrophage differentiation
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0032092 positive regulation of protein binding
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033085 negative regulation of T cell differentiation in thymus
GO:0033088 negative regulation of immature T cell proliferation in thymus
GO:0034504 protein localization to nucleus
GO:0035116 embryonic hindlimb morphogenesis
GO:0035990 tendon cell differentiation
GO:0035993 deltoid tuberosity development
GO:0039706 co-receptor binding
GO:0042056 chemoattractant activity
GO:0042306 regulation of protein import into nucleus
GO:0042326 negative regulation of phosphorylation
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043401 steroid hormone mediated signaling pathway
GO:0043407 negative regulation of MAP kinase activity
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045606 positive regulation of epidermal cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045786 negative regulation of cell cycle
GO:0045839 negative regulation of mitotic nuclear division
GO:0045843 negative regulation of striated muscle tissue development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048286 lung alveolus development
GO:0048392 intermediate mesodermal cell differentiation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048663 neuron fate commitment
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048745 smooth muscle tissue development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051150 regulation of smooth muscle cell differentiation
GO:0055007 cardiac muscle cell differentiation
GO:0055020 positive regulation of cardiac muscle fiber development
GO:0060113 inner ear receptor cell differentiation
GO:0060197 cloacal septation
GO:0060235 lens induction in camera-type eye
GO:0060272 embryonic skeletal joint morphogenesis
GO:0060363 cranial suture morphogenesis
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060425 lung morphogenesis
GO:0060433 bronchus development
GO:0060438 trachea development
GO:0060440 trachea formation
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060442 branching involved in prostate gland morphogenesis
GO:0060449 bud elongation involved in lung branching
GO:0060502 epithelial cell proliferation involved in lung morphogenesis
GO:0060503 bud dilation involved in lung branching
GO:0060548 negative regulation of cell death
GO:0060592 mammary gland formation
GO:0060684 epithelial-mesenchymal cell signaling
GO:0060686 negative regulation of prostatic bud formation
GO:0060687 regulation of branching involved in prostate gland morphogenesis
GO:0060976 coronary vasculature development
GO:0061036 positive regulation of cartilage development
GO:0061047 positive regulation of branching involved in lung morphogenesis
GO:0061149 BMP signaling pathway involved in ureter morphogenesis
GO:0061151 BMP signaling pathway involved in renal system segmentation
GO:0061155 pulmonary artery endothelial tube morphogenesis
GO:0061312 BMP signaling pathway involved in heart development
GO:0061626 pharyngeal arch artery morphogenesis
GO:0070244 negative regulation of thymocyte apoptotic process
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070700 BMP receptor binding
GO:0071773 cellular response to BMP stimulus
GO:0071893 BMP signaling pathway involved in nephric duct formation
GO:0072015 glomerular visceral epithelial cell development
GO:0072097 negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
GO:0072101 specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
GO:0072104 glomerular capillary formation
GO:0072125 negative regulation of glomerular mesangial cell proliferation
GO:0072138 mesenchymal cell proliferation involved in ureteric bud development
GO:0072161 mesenchymal cell differentiation involved in kidney development
GO:0072192 ureter epithelial cell differentiation
GO:0072193 ureter smooth muscle cell differentiation
GO:0072198 mesenchymal cell proliferation involved in ureter development
GO:0072200 negative regulation of mesenchymal cell proliferation involved in ureter development
GO:0072205 metanephric collecting duct development
GO:0090184 positive regulation of kidney development
GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis
GO:0090194 negative regulation of glomerulus development
GO:1901964 positive regulation of cell proliferation involved in outflow tract morphogenesis
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:1905312 positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:2000005 negative regulation of metanephric S-shaped body morphogenesis
GO:2000007 negative regulation of metanephric comma-shaped body morphogenesis
GO:2000137 negative regulation of cell proliferation involved in heart morphogenesis
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Diseases

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Interactions

107 interactions

InteractorPartnerSourcesPublicationsLink
BMP4ZFYVE9BioGRID, HPRD, MINT15231748 details
BMP4FSTL1MINT20860622 details
BMP4BMPR1ABioGRID, HPRD, MINT11241215 20860622 21054789 27684187 28126904 7644468 8006002 8702914 details
BMP4WFIKKN1MINT21054789 details
BMP4WFIKKN2MINT21054789 details
BMP4TWSG1BioGRID, IntAct11260715 28514442 details
BMP4BMPR2BioGRID, HPRD12045205 28126904 7644468 8702914 details
BMP4BMPR1BBioGRID, HPRD11282024 7811286 8006002 8702914 details
BMP4RGMBBioGRID15671031 details
BMP4TDGF1BioGRID28126904 details
BMP4ACVR2ABioGRID28126904 details
BMP4C12orf60IntAct25416956 details
BMP4SOSTDC1BioGRID, HPRD15020244 details
BMP4BMP4HPRD7644468 7673243 details
BMP4HTRA1HPRD14973287 details
BMP4BMP8BHPRD10894154 11427739 details
BMP4NOGHPRD10657699 11706034 details
BMP4STAP2HPRD7644468 details
BMP4CHRDL2HPRD14660436 details
BMP4BMPERHPRD12897139 details
BMP4GREM2HPRD15039429 details
BMP4BGNHPRD15173106 15775969 details
BMP4CHRDL1HPRD11441185 details
BMP4SUFUBioGRID, IntAct28514442 details
BMP4PDP1BioGRID, IntAct28514442 details
BMP4DCAF16BioGRID, IntAct28514442 details
BMP4UBE2OBioGRID, IntAct28514442 details
BMP4CALRBioGRID, IntAct28514442 details
BMP4PROS1BioGRID, IntAct28514442 details
BMP4SLC22A23BioGRID, IntAct28514442 details
BMP4RPL18BioGRID27684187 details
BMP4RPL26BioGRID27684187 details
BMP4RPS13BioGRID27684187 details
BMP4RPS9BioGRID27684187 details
BMP4RPL8BioGRID27684187 details
BMP4PABPC1BioGRID27684187 details
BMP4RPL35ABioGRID27684187 details
BMP4HNF1BBioGRID27684187 details
BMP4RPS20BioGRID27684187 details
BMP4RPS6BioGRID27684187 details
BMP4PCBP1BioGRID27684187 details
BMP4RPL7BioGRID27684187 details
BMP4H1-2BioGRID27684187 details
BMP4RPS3BioGRID27684187 details
BMP4RPL27ABioGRID27684187 details
BMP4ZNF622BioGRID27684187 details
BMP4FBLBioGRID27684187 details
BMP4RPL3BioGRID27684187 details
BMP4RPL27BioGRID27684187 details
BMP4RPL14BioGRID27684187 details
BMP4STAU1BioGRID27684187 details
BMP4NPM1BioGRID27684187 details
BMP4SRRM2BioGRID27684187 details
BMP4SRPK1BioGRID27684187 details
BMP4YBX1BioGRID27684187 details
BMP4RPL18ABioGRID27684187 details
BMP4PTBP1BioGRID27684187 details
BMP4RPL9BioGRID27684187 details
BMP4EWSR1BioGRID27684187 details
BMP4RPS11BioGRID27684187 details
BMP4HSPA5BioGRID27684187 details
BMP4HNRNPA1BioGRID27684187 details
BMP4RPS15ABioGRID27684187 details
BMP4RPL12BioGRID27684187 details
BMP4HNRNPUBioGRID27684187 details
BMP4RPL23BioGRID27684187 details
BMP4RPS8BioGRID27684187 details
BMP4RPL23ABioGRID27684187 details
BMP4RPL21BioGRID27684187 details
BMP4RPS23BioGRID27684187 details
BMP4CLUBioGRID27684187 details
BMP4RBM39BioGRID27684187 details
BMP4DIMT1BioGRID27684187 details
BMP4RPL6BioGRID27684187 details
BMP4HNRNPMBioGRID27684187 details
BMP4UPF1BioGRID27684187 details
BMP4KIAA1522BioGRID27684187 details
BMP4RPLP0BioGRID27684187 details
BMP4RPL4BioGRID27684187 details
BMP4MRPS15BioGRID27684187 details
BMP4SART1BioGRID27684187 details
BMP4RPL28BioGRID27684187 details
BMP4DDX54BioGRID27684187 details
BMP4DDX18BioGRID27684187 details
BMP4TOP1BioGRID27684187 details
BMP4KHDRBS1BioGRID27684187 details
BMP4SYNCRIPBioGRID27684187 details
BMP4RPL5BioGRID27684187 details
BMP4PUF60BioGRID27684187 details
BMP4RPL22BioGRID27684187 details
BMP4RPS3ABioGRID27684187 details
BMP4RPL10BioGRID27684187 details
BMP4SRPK2BioGRID27684187 details
BMP4EIF4A3BioGRID27684187 details
BMP4RPL36BioGRID27684187 details
BMP4DHX9BioGRID27684187 details
BMP4RPL31BioGRID27684187 details
BMP4RPS7BioGRID27684187 details
BMP4GTPBP4BioGRID27684187 details
BMP4H1-10BioGRID27684187 details
BMP4H1-4BioGRID27684187 details
BMP4RPL19BioGRID27684187 details
BMP4RPL11BioGRID27684187 details
BMP4FXR2BioGRID27684187 details
BMP4RPL13BioGRID27684187 details
BMP4MAP4BioGRID27684187 details
BMP4DNAJA1BioGRID27684187 details