Entity Details

Primary name SMO
Entity type gene
Source Source Link

Details

PrimaryID6608
RefseqGeneNG_023340
SymbolSMO
Namesmoothened, frizzled class receptor
Chromosome7
Location7q32.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-07-22
ModificationDate2021-06-12

Ontological Relatives

UniProt IDsSMO_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001570 vasculogenesis
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001708 cell fate specification
GO:0001755 neural crest cell migration
GO:0001947 heart looping
GO:0002052 positive regulation of neuroblast proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0003140 determination of left/right asymmetry in lateral mesoderm
GO:0003323 type B pancreatic cell development
GO:0004930 G protein-coupled receptor activity
GO:0005113 patched binding
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0007224 smoothened signaling pathway
GO:0007228 positive regulation of hh target transcription factor activity
GO:0007371 ventral midline determination
GO:0007417 central nervous system development
GO:0007494 midgut development
GO:0009952 anterior/posterior pattern specification
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016021 integral component of membrane
GO:0021542 dentate gyrus development
GO:0021696 cerebellar cortex morphogenesis
GO:0021794 thalamus development
GO:0021904 dorsal/ventral neural tube patterning
GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning
GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021953 central nervous system neuron differentiation
GO:0021987 cerebral cortex development
GO:0030335 positive regulation of cell migration
GO:0030425 dendrite
GO:0030666 endocytic vesicle membrane
GO:0030857 negative regulation of epithelial cell differentiation
GO:0031069 hair follicle morphogenesis
GO:0034504 protein localization to nucleus
GO:0035264 multicellular organism growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042307 positive regulation of protein import into nucleus
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043392 negative regulation of DNA binding
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046622 positive regulation of organ growth
GO:0048143 astrocyte activation
GO:0048741 skeletal muscle fiber development
GO:0048745 smooth muscle tissue development
GO:0048853 forebrain morphogenesis
GO:0048873 homeostasis of number of cells within a tissue
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050821 protein stabilization
GO:0051451 myoblast migration
GO:0051799 negative regulation of hair follicle development
GO:0060170 ciliary membrane
GO:0060242 contact inhibition
GO:0060413 atrial septum morphogenesis
GO:0060644 mammary gland epithelial cell differentiation
GO:0060684 epithelial-mesenchymal cell signaling
GO:0061053 somite development
GO:0061113 pancreas morphogenesis
GO:0070062 extracellular exosome
GO:0070986 left/right axis specification
GO:0071397 cellular response to cholesterol
GO:0071679 commissural neuron axon guidance
GO:0072285 mesenchymal to epithelial transition involved in metanephric renal vesicle formation
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:0097542 ciliary tip
GO:0097731 9+0 non-motile cilium
GO:2000036 regulation of stem cell population maintenance
GO:2000826 regulation of heart morphogenesis

Diseases

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Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
SMOILKMINT23877428 details
SMOARRB2MINT23877428 details
SMOARRB1MINT23877428 details
SMOARV1BioGRID, MINT28298427 details
SMONDFIP1BioGRID, MINT28298427 details
SMOJPH3BioGRID, MINT28298427 details
SMONIPA1BioGRID, MINT28298427 details
SMOSLC41A3BioGRID, MINT28298427 details
SMOSSPNBioGRID, MINT28298427 details
SMORPN2BioGRID, MINT28298427 details
SMOLEPROTBioGRID, MINT28298427 details
SMOPLPP7BioGRID, MINT28298427 details
SMOC18orf32BioGRID, MINT28298427 details
SMOEMC10BioGRID, MINT28298427 details
SMOTIMMDC1BioGRID, MINT28298427 details
SMOS1PR5BioGRID, MINT28298427 details
SMOFKBP8BioGRID, MINT28298427 details
SMOWLSBioGRID, MINT28298427 details
SMOGABARAPL2BioGRID, MINT28298427 details
SMOGABBR1BioGRID, MINT28298427 details
SMOC4orf3BioGRID, MINT28298427 details
SMOHMOX1BioGRID, MINT28298427 details
SMOHMOX2BioGRID, MINT28298427 details
SMOHMGN4BioGRID, MINT28298427 details
SMOITGB1BP1BioGRID, MINT28298427 details
SMONGEFBioGRID, MINT28298427 details
SMOTSPAN7BioGRID, MINT28298427 details
SMOTMCC2BioGRID, MINT28298427 details
SMONEDD4BioGRID23106887 details
SMOPTCH1bhf-ucl, BioGRID, HPRD11278759 9811851 details
SMOPTCH2BioGRID, HPRD9811851 details
SMOGNAI1BioGRID31168089 details
SMOGNB1BioGRID31168089 details
SMOGNGT1BioGRID31168089 details
SMOHERC4BioGRID31010679 details
SMOGRK2BioGRID31253779 details
SMOBCL6BioGRID, IntAct16147992 details
SMOFAM189BBioGRID, IntAct28514442 details
SMOGNG2DIP31168089 details
SMORAB11ABioGRID34079125 details
SMOSTX7BioGRID34079125 details