Entity Details

Primary name CXCR4
Entity type gene
Source Source Link

Details

PrimaryID7852
RefseqGeneNG_011587
SymbolCXCR4
NameC-X-C motif chemokine receptor 4
Chromosome2
Location2q22.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-09-21
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsCXCR4_HUMAN

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001618 virus receptor activity
GO:0001666 response to hypoxia
GO:0001764 neuron migration
GO:0002064 epithelial cell development
GO:0002407 dendritic cell chemotaxis
GO:0003779 actin binding
GO:0004930 G protein-coupled receptor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007411 axon guidance
GO:0007420 brain development
GO:0008038 neuron recognition
GO:0009615 response to virus
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0014823 response to activity
GO:0015026 coreceptor activity
GO:0016021 integral component of membrane
GO:0016493 C-C chemokine receptor activity
GO:0016494 C-X-C chemokine receptor activity
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0019722 calcium-mediated signaling
GO:0019957 C-C chemokine binding
GO:0022008 neurogenesis
GO:0022029 telencephalon cell migration
GO:0030054 cell junction
GO:0030155 regulation of cell adhesion
GO:0031252 cell leading edge
GO:0031410 cytoplasmic vesicle
GO:0031625 ubiquitin protein ligase binding
GO:0032027 myosin light chain binding
GO:0032991 protein-containing complex
GO:0035470 positive regulation of vascular wound healing
GO:0035690 cellular response to drug
GO:0038147 C-X-C motif chemokine 12 receptor activity
GO:0038160 CXCL12-activated CXCR4 signaling pathway
GO:0043067 regulation of programmed cell death
GO:0043130 ubiquitin binding
GO:0043217 myelin maintenance
GO:0043278 response to morphine
GO:0044409 entry into host
GO:0045446 endothelial cell differentiation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0050792 regulation of viral process
GO:0050920 regulation of chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051924 regulation of calcium ion transport
GO:0060048 cardiac muscle contraction
GO:0060326 cell chemotaxis
GO:0061154 endothelial tube morphogenesis
GO:0070062 extracellular exosome
GO:0071345 cellular response to cytokine stimulus
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1903861 positive regulation of dendrite extension
GO:1905322 positive regulation of mesenchymal stem cell migration
GO:1990478 response to ultrasound
GO:2000448 positive regulation of macrophage migration inhibitory factor signaling pathway

Diseases

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Interactions

78 interactions

InteractorPartnerSourcesPublicationsLink
CXCR4CCR5BioGRID, DIP, HPRD, IntAct12429730 15660419 18632580 details
CXCR4TLR2DIP, I2D18765807 20802527 details
CXCR4MYBL2BioGRID, IntAct21988832 details
CXCR4ATP13A2BioGRID, IntAct22645275 details
CXCR4ACKR3IntAct19380869 21730065 25775528 27331810 28862946 29386406 details
CXCR4CXCR4HPRD, IntAct10506573 12433920 19380869 23170857 details
CXCR4GNAI1HPRD, IntAct10506573 19380869 details
CXCR4CXCR3IntAct23170857 details
CXCR4ITCHBioGRID19116316 22275353 24489825 28264927 details
CXCR4USP14BioGRID19106094 details
CXCR4B2MBioGRID18083706 details
CXCR4RNF113ABioGRID28978524 details
CXCR4MYH9HPRD, IntAct12421915 details
CXCR4CD74MINT19665027 details
CXCR4CXCL14MINT23669361 details
CXCR4DBN1IntAct20215400 23926103 details
CXCR4CD164Molecular Connections24094005 details
CXCR4CXCR5BioGRID, Molecular Connections23773523 details
CXCR4GNA13BioGRID, HPRD, Molecular Connections11994484 23773523 details
CXCR4PECAM1IntAct24497640 details
CXCR4CD4BioGRID, HPRD, UniProt10816381 14592831 15660419 details
CXCR4SLC1A1BioGRID, IntAct27173435 unassigned1312 details
CXCR4ADRA1AIntAct25775528 27331810 28862946 details
CXCR4ADRA1DIntAct28862946 29426850 details
CXCR4ADRA1BIntAct25775528 28862946 29426850 details
CXCR4AVPR1AIntAct29386406 details
CXCR4PTPRCHPRD, MINT12519755 21912642 details
CXCR4JAK3BioGRID, HPRD10506573 details
CXCR4JAK2BioGRID, HPRD10506573 details
CXCR4PTPN6BioGRID, HPRD10506573 details
CXCR4GRK3BioGRID, HPRD11668182 details
CXCR4PTK2BioGRID11668182 details
CXCR4SOCS3BioGRID, HPRD12163560 details
CXCR4STAMBioGRID20505072 22275353 details
CXCR4CAV1BioGRID22275353 details
CXCR4PTPN11BioGRID, HPRD11157475 details
CXCR4CXCL12BioGRID, HPRD10233851 21757744 25495026 8752281 details
CXCR4ST13BioGRID11751889 details
CXCR4P4HBBioGRID14592831 details
CXCR4HLA-BBioGRID18083706 details
CXCR4MTSS1BioGRID28264927 details
CXCR4HMGB1BioGRID25495026 details
CXCR4SOCS1BioGRID, HPRD12163560 29991678 details
CXCR4HIF1ABioGRID17083723 details
CXCR4UBCBioGRID30195032 details
CXCR4IQGAP1BioGRID30948266 details
CXCR4RALABioGRID30948266 details
CXCR4BIRC3BioGRID30948266 details
CXCR4SDC4HPRD15819887 details
CXCR4STAT1HPRD10506573 details
CXCR4STAT2HPRD10506573 details
CXCR4STAT3HPRD10506573 details
CXCR4STAT5BHPRD10506573 details
CXCR4JAK1HPRD12163560 details
CXCR4HSPA8HPRD16365278 details
CXCR4DPP4HPRD11278278 details
CXCR4VAV1HPRD15618472 details
CXCR4ARRB2HPRD10644702 details
CXCR4CTSGHPRD12531874 details
CXCR4ELANEHPRD12531874 details
CXCR4TMEM63BBioGRID, IntAct26496610 details
CXCR4GOLT1BBioGRID, IntAct26496610 details
CXCR4LPAR1BioGRID, IntAct28514442 details
CXCR4IPPKBioGRID, IntAct28514442 details
CXCR4VIPR2BioGRID, IntAct28514442 details
CXCR4NTRK3BioGRID, IntAct28514442 details
CXCR4GCNT3BioGRID, IntAct28514442 details
CXCR4CD79BBioGRID, IntAct28514442 details
CXCR4CCDC107BioGRID, IntAct28514442 details
CXCR4NT5EBioGRID, IntAct28514442 details
CXCR4B4GAT1BioGRID, IntAct28514442 details
CXCR4TMEM171BioGRID, IntAct28514442 details
CXCR4UNC93B1BioGRID, IntAct30833792 details
CXCR4RELAI2D21383699 details
CXCR4CDK9IntAct23746844 details
CXCR4POLR2AIntAct23746844 details
CXCR4CDK8IntAct23746844 details
CXCR4DDX58BioGRID32513696 details