Entity Details

Primary name KLF4
Entity type gene
Source Source Link

Details

PrimaryID9314
RefseqGene
SymbolKLF4
NameKruppel like factor 4
Chromosome9
Location9q31.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-03
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsKLF4_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity
GO:0001221 transcription coregulator binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002357 defense response to tumor cell
GO:0003700 DNA-binding transcription factor activity
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007500 mesodermal cell fate determination
GO:0008013 beta-catenin binding
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0009913 epidermal cell differentiation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0014740 negative regulation of muscle hyperplasia
GO:0016525 negative regulation of angiogenesis
GO:0019827 stem cell population maintenance
GO:0031077 post-embryonic camera-type eye development
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032717 negative regulation of interleukin-8 production
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0035014 phosphatidylinositol 3-kinase regulator activity
GO:0035019 somatic stem cell population maintenance
GO:0035166 post-embryonic hemopoiesis
GO:0042826 histone deacetylase binding
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045444 fat cell differentiation
GO:0045595 regulation of cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046985 positive regulation of hemoglobin biosynthetic process
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0048679 regulation of axon regeneration
GO:0048730 epidermis morphogenesis
GO:0050728 negative regulation of inflammatory response
GO:0051247 positive regulation of protein metabolic process
GO:0051898 negative regulation of protein kinase B signaling
GO:0051973 positive regulation of telomerase activity
GO:0060070 canonical Wnt signaling pathway
GO:0060761 negative regulation of response to cytokine stimulus
GO:0070301 cellular response to hydrogen peroxide
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071300 cellular response to retinoic acid
GO:0071363 cellular response to growth factor stimulus
GO:0071409 cellular response to cycloheximide
GO:0071499 cellular response to laminar fluid shear stress
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:0120222 regulation of blastocyst development
GO:1901653 cellular response to peptide
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903672 positive regulation of sprouting angiogenesis
GO:1904798 positive regulation of core promoter binding
GO:1904998 negative regulation of leukocyte adhesion to arterial endothelial cell
GO:1990830 cellular response to leukemia inhibitory factor
GO:1990837 sequence-specific double-stranded DNA binding
GO:1990841 promoter-specific chromatin binding
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production

Diseases

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Interactions

63 interactions

InteractorPartnerSourcesPublicationsLink
KLF4DVL3BioGRID, IntAct32296183 details
KLF4TLE5BioGRID, IntAct32296183 details
KLF4PAX9BioGRID, IntAct32296183 details
KLF4GYS1BioGRID, IntAct32296183 details
KLF4HGSBioGRID, IntAct32296183 details
KLF4HSF2BPBioGRID, IntAct32296183 details
KLF4YAP1DIP25531778 details
KLF4CREBBPBioGRID10666450 17908689 21482710 21539536 details
KLF4SP1BioGRID22282354 9651398 details
KLF4HDAC2BioGRID15561714 19486889 21252119 details
KLF4HDAC1BioGRID15561714 details
KLF4EP300BioGRID17908689 20711222 21252119 21482710 details
KLF4KAT5BioGRID17827213 details
KLF4VHLBioGRID22284679 details
KLF4APPBioGRID21832049 details
KLF4SETD7BioGRID25042802 details
KLF4HUWE1BioGRID28084302 details
KLF4BAALCBioGRID26050649 details
KLF4FBXO7BioGRID27503909 details
KLF4MYO15BBioGRID32296183 details
KLF4PLK1BioGRID31281496 details
KLF4USP10BioGRID31748695 details
KLF4CTBP1BioGRID, MINT19751731 details
KLF4KDM6BDIP22801502 details
KLF4KDM6ADIP22801502 details
KLF4MBD3DIP24048479 details
KLF4ESR1BioGRID, IntAct23403292 31527615 details
KLF4KLF6BioGRID10802067 details
KLF4ELK1BioGRID18768922 details
KLF4HDAC5BioGRID18768922 details
KLF4HDAC7BioGRID17827213 details
KLF4SMARCA4BioGRID20305087 details
KLF4PPARGBioGRID22282354 details
KLF4RELABioGRID22282354 details
KLF4PRKCDBioGRID22282354 details
KLF4CUL2BioGRID22284679 details
KLF4ELOBBioGRID22284679 details
KLF4CDH1BioGRID21177849 details
KLF4FBXO22BioGRID26087183 details
KLF4FBXO32BioGRID28068319 details
KLF4TRAF6BioGRID31281496 details
KLF4USP4BioGRID31748695 details
KLF4USP6BioGRID31748695 details
KLF4USP7BioGRID31748695 details
KLF4ATXN3BioGRID31563563 details
KLF4AURKABioGRID, IntAct26496610 details
KLF4CUL1BioGRID26087183 details
KLF4SKP1BioGRID26087183 details
KLF4H4C1BioGRID30804502 details
KLF4SPI1IntAct17762869 details
KLF4CCL1IntAct33179750 details
KLF4CCL13IntAct33179750 details
KLF4CCL28IntAct33179750 details
KLF4CXCL3IntAct33179750 details
KLF4IFNL1IntAct33179750 details
KLF4IL15IntAct33179750 details
KLF4IL23AIntAct33179750 details
KLF4IL31IntAct33179750 details
KLF4IL32IntAct33179750 details
KLF4IL7IntAct33179750 details
KLF4OSMIntAct33179750 details
KLF4TNFSF10IntAct33179750 details
KLF4XCL2IntAct33179750 details