Entity Details

Primary name NR1H4
Entity type gene
Source Source Link

Details

PrimaryID9971
RefseqGeneNG_029843
SymbolNR1H4
Namenuclear receptor subfamily 1 group H member 4
Chromosome12
Location12q23.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-21
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsNR1H4_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001678 cellular glucose homeostasis
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005654 nucleoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006954 inflammatory response
GO:0007043 cell-cell junction assembly
GO:0007219 Notch signaling pathway
GO:0008206 bile acid metabolic process
GO:0008270 zinc ion binding
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling
GO:0010988 regulation of low-density lipoprotein particle clearance
GO:0015721 bile acid and bile salt transport
GO:0016922 nuclear receptor binding
GO:0030154 cell differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0032052 bile acid binding
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032689 negative regulation of interferon-gamma production
GO:0032692 negative regulation of interleukin-1 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032740 positive regulation of interleukin-17 production
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034255 regulation of urea metabolic process
GO:0034971 histone H3-R17 methylation
GO:0035356 cellular triglyceride homeostasis
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0038181 bile acid receptor activity
GO:0038183 bile acid signaling pathway
GO:0038185 intracellular bile acid receptor signaling pathway
GO:0042632 cholesterol homeostasis
GO:0042742 defense response to bacterium
GO:0043066 negative regulation of apoptotic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043235 receptor complex
GO:0043565 sequence-specific DNA binding
GO:0045087 innate immune response
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046965 retinoid X receptor binding
GO:0050728 negative regulation of inflammatory response
GO:0055089 fatty acid homeostasis
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070857 regulation of bile acid biosynthetic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071398 cellular response to fatty acid
GO:0071417 cellular response to organonitrogen compound
GO:0071638 negative regulation of monocyte chemotactic protein-1 production
GO:0090181 regulation of cholesterol metabolic process
GO:1902122 chenodeoxycholic acid binding
GO:1903413 cellular response to bile acid
GO:1904179 positive regulation of adipose tissue development
GO:1905695 positive regulation of phosphatidic acid biosynthetic process
GO:2000213 positive regulation of glutamate metabolic process
GO:2001250 positive regulation of ammonia assimilation cycle

Diseases

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Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
NR1H4SMARCD1BioGRID, IntAct12917342 details
NR1H4GRB2IntAct17474147 details
NR1H4NCOA1BioGRID, DIP, HPRD, UniProt11136553 14684751 14698205 18391212 20338915 details
NR1H4SETD7UniProt22345554 details
NR1H4PRKDCBioGRID, UniProt19833092 details
NR1H4XRCC6BioGRID, UniProt19833092 details
NR1H4XRCC5BioGRID, UniProt19833092 details
NR1H4RXRBBioGRID, IntAct26871637 28514442 32296183 details
NR1H4RXRGBioGRID, HPRD, IntAct15604093 32296183 details
NR1H4PPARGC1ABioGRID, HPRD14729567 details
NR1H4RXRABioGRID, HPRD19883617 7760852 details
NR1H4CASP8BioGRID, HPRD11733517 details
NR1H4H3C1BioGRID15471871 details
NR1H4NCOA6BioGRID21330447 details
NR1H4EP300BioGRID19883617 details
NR1H4SIRT1BioGRID19883617 details
NR1H4GAPDHBioGRID, HPRD15604093 details
NR1H4NCOR2BioGRID, HPRD16219912 details
NR1H4SMARCD3BioGRID, HPRD14701856 details
NR1H4ESR1BioGRID, HPRD, IntAct17333335 25675114 details
NR1H4RELAI2D21499302 details
NR1H4SREBF2IntAct24321096 details
NR1H4NCOR1BioGRID18978041 details
NR1H4PRMT1BioGRID15911693 details
NR1H4CARM1BioGRID15471871 details
NR1H4GPS2BioGRID17895379 details
NR1H4RRM2BioGRID22632967 details
NR1H4SUMO1BioGRID23546875 details
NR1H4HDAC6BioGRID23703321 details
NR1H4PSMD14BioGRID30745168 details
NR1H4FGF19IntAct22561792 24321096 details
NR1H4ABCB11IntAct25675114 details
NR1H4CCL1IntAct33179750 details
NR1H4CCL15IntAct33179750 details
NR1H4CCL28IntAct33179750 details
NR1H4CCL4IntAct33179750 details
NR1H4CXCL3IntAct33179750 details
NR1H4IFNA10IntAct33179750 details
NR1H4IFNA17IntAct33179750 details
NR1H4IFNA16IntAct33179750 details
NR1H4IFNA7IntAct33179750 details
NR1H4IFNA8IntAct33179750 details
NR1H4IL17AIntAct33179750 details
NR1H4IL17FIntAct33179750 details
NR1H4IL20IntAct33179750 details
NR1H4IL25IntAct33179750 details
NR1H4IL31IntAct33179750 details
NR1H4IL32IntAct33179750 details
NR1H4IL7IntAct33179750 details
NR1H4OSMIntAct33179750 details
NR1H4TNFSF13IntAct33179750 details
NR1H4TNFSF8IntAct33179750 details