Entity Details

Primary name TTBK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ5TCY1
EntryNameTTBK1_HUMAN
FullNameTau-tubulin kinase 1
TaxID9606
Evidenceevidence at protein level
Length1321
SequenceStatuscomplete
DateCreated2006-05-16
DateModified2021-06-02

Ontological Relatives

GenesTTBK1

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005875 microtubule associated complex
GO:0006468 protein phosphorylation
GO:0007611 learning or memory
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021762 substantia nigra development
GO:0032091 negative regulation of protein binding
GO:0032273 positive regulation of protein polymerization
GO:0043025 neuronal cell body
GO:0048156 tau protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0050321 tau-protein kinase activity
GO:0061890 positive regulation of astrocyte activation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903980 positive regulation of microglial cell activation
GO:1904031 positive regulation of cyclin-dependent protein kinase activity
GO:2001056 positive regulation of cysteine-type endopeptidase activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR042714 Tau-tubulin kinase 1, catalytic domainDomainDomain

Diseases

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