Entity Details

Primary name LRC8D_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ7L1W4
EntryNameLRC8D_HUMAN
FullNameVolume-regulated anion channel subunit LRRC8D
TaxID9606
Evidenceevidence at protein level
Length858
SequenceStatuscomplete
DateCreated2004-08-31
DateModified2021-06-02

Ontological Relatives

GenesLRRC8D

GO terms

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GOName
GO:0001678 cellular glucose homeostasis
GO:0005225 volume-sensitive anion channel activity
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0015734 taurine transport
GO:0015810 aspartate transmembrane transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0034214 protein hexamerization
GO:0034702 ion channel complex
GO:0055085 transmembrane transport
GO:0071470 cellular response to osmotic stress
GO:0098656 anion transmembrane transport

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR021040 LRRC8, pannexin-like TM regionDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
LRC8D_HUMANEXOS4_HUMANBioGRID, HPRD, IntAct15231747 details
LRC8D_HUMANA4_HUMANBioGRID21244100 21832049 details
LRC8D_HUMANLRC8A_HUMANDIP24790029 details