Entity Details

Primary name RFX6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8HWS3
EntryNameRFX6_HUMAN
FullNameDNA-binding protein RFX6
TaxID9606
Evidenceevidence at protein level
Length928
SequenceStatuscomplete
DateCreated2008-01-15
DateModified2021-06-02

Ontological Relatives

GenesRFX6

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003309 type B pancreatic cell differentiation
GO:0003310 pancreatic A cell differentiation
GO:0003311 pancreatic D cell differentiation
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0031018 endocrine pancreas development
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042593 glucose homeostasis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050796 regulation of insulin secretion
GO:0090104 pancreatic epsilon cell differentiation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR003150 DNA-binding RFX-type winged-helix domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR039779 RFX-like DNA-binding proteinFamilyFamily

Diseases

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Disease IDSourceNameDescription
615710 OMIMMitchell-Riley syndrome (MTCHRS)A disorder characterized by neonatal diabetes, hypoplastic or annular pancreas, duodenal and jejunal atresia, and absent gallbladder. There is no dysmorphic features. The disease is caused by variants affecting the gene represented in this entry.

Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
RFX6_HUMANCCNK_HUMANBioGRID, HPRD, IntAct16189514 details
RFX6_HUMANRFX2_HUMANBioGRID, HPRD, IntAct16189514 32296183 details
RFX6_HUMANCREST_HUMANBioGRID, IntAct16189514 32296183 details
RFX6_HUMANDTX2_HUMANBioGRID, HPRD, IntAct16189514 25416956 details
RFX6_HUMANFHL3_HUMANBioGRID, HPRD, IntAct16189514 details
RFX6_HUMANLMO3_HUMANBioGRID, HPRD, IntAct16189514 details
RFX6_HUMANRFX3_HUMANBioGRID, HPRD, IntAct16189514 details
RFX6_HUMANRSMB_HUMANBioGRID, IntAct, MINT21516116 25416956 32296183 details
RFX6_HUMANRIPK3_HUMANBioGRID, IntAct21988832 details
RFX6_HUMANCYFP1_HUMANBioGRID, IntAct21988832 details
RFX6_HUMANVP37C_HUMANBioGRID, IntAct25416956 details
RFX6_HUMANFRS3_HUMANBioGRID, IntAct25416956 32296183 details
RFX6_HUMANSTK16_HUMANBioGRID, IntAct25416956 details
RFX6_HUMANAAPK2_HUMANBioGRID, IntAct25416956 details
RFX6_HUMANTLE5_HUMANBioGRID, IntAct25416956 details
RFX6_HUMANAAPK1_HUMANBioGRID, IntAct25416956 details
RFX6_HUMANCASL_HUMANBioGRID, IntAct25416956 32296183 details
RFX6_HUMANPKHN1_HUMANBioGRID, IntAct25416956 details
RFX6_HUMANCTSR1_HUMANBioGRID, IntAct25416956 32296183 details
RFX6_HUMANESR2_HUMANBioGRID, IntAct24722188 details
RFX6_HUMANKIF1A_HUMANBioGRID, IntAct24722188 details
RFX6_HUMANPITX1_HUMANBioGRID, IntAct24722188 details
RFX6_HUMANHGS_HUMANBioGRID, IntAct26871637 details
RFX6_HUMANKCTD9_HUMANBioGRID, IntAct32296183 details
RFX6_HUMANCSTF2_HUMANBioGRID, IntAct32296183 details
RFX6_HUMANTEKT3_HUMANBioGRID, IntAct32296183 details
RFX6_HUMANMEMO1_HUMANBioGRID, IntAct32296183 details
RFX6_HUMANUBP2_HUMANBioGRID, IntAct32296183 details
RFX6_HUMANZMY19_HUMANBioGRID, IntAct32296183 details
RFX6_HUMANTET5B_HUMANBioGRID, IntAct32296183 details
RFX6_HUMANTEKT4_HUMANBioGRID, IntAct32296183 details
RFX6_HUMANDUS21_HUMANBioGRID, IntAct32296183 details
RFX6_HUMANDMRT3_HUMANBioGRID, IntAct32296183 details
RFX6_HUMANPPR32_HUMANBioGRID, IntAct32296183 details
RFX6_HUMANPATZ1_HUMANBioGRID, IntAct32296183 details
RFX6_HUMANLEG4_HUMANBioGRID, IntAct32296183 details
RFX6_HUMANSPYA_HUMANBioGRID, IntAct32296183 details
RFX6_HUMANARNT2_HUMANBioGRID24722188 details
RFX6_HUMANDGCR6_HUMANBioGRID24722188 details
RFX6_HUMANRU1C_HUMANBioGRID25416956 details
RFX6_HUMANZN688_HUMANBioGRID26871637 details