Entity Details

Primary name PMYT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99640
EntryNamePMYT1_HUMAN
FullNameMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
TaxID9606
Evidenceevidence at protein level
Length499
SequenceStatuscomplete
DateCreated2004-11-23
DateModified2021-06-02

Ontological Relatives

GenesPKMYT1

GO terms

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GOName
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000139 Golgi membrane
GO:0000278 mitotic cell cycle
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0007088 regulation of mitotic nuclear division
GO:0010923 negative regulation of phosphatase activity
GO:0016020 membrane
GO:0016301 kinase activity
GO:0046872 metal ion binding
GO:0051321 meiotic cell cycle
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016235 Tyrosine/threonine-protein kinase, Cdc2 inhibitorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
PMYT1_HUMANCDK1_HUMANBioGRID, HPRD, IntAct, UniProt10373560 10504341 12912980 23602568 25852190 26186194 28514442 9001210 9268380 details
PMYT1_HUMANPP1A_HUMANUniProt19389623 details
PMYT1_HUMANFATE1_HUMANBioGRID, IntAct32296183 details
PMYT1_HUMANLRC25_HUMANBioGRID, IntAct32296183 details
PMYT1_HUMANABHGA_HUMANBioGRID, IntAct32296183 details
PMYT1_HUMANNTCP_HUMANBioGRID, IntAct32296183 details
PMYT1_HUMANCLD8_HUMANBioGRID, IntAct32296183 details
PMYT1_HUMANLIME1_HUMANBioGRID, IntAct32296183 details
PMYT1_HUMANMF14B_HUMANBioGRID, IntAct32296183 details
PMYT1_HUMANTMX2_HUMANBioGRID, IntAct32296183 details
PMYT1_HUMANELOV4_HUMANBioGRID, IntAct32296183 details
PMYT1_HUMANTM101_HUMANBioGRID, IntAct32296183 details
PMYT1_HUMANRETR3_HUMANBioGRID, IntAct32296183 details
PMYT1_HUMANCD3E_HUMANBioGRID, IntAct32296183 details
PMYT1_HUMANT229B_HUMANBioGRID, IntAct32296183 details
PMYT1_HUMANMFSD5_HUMANBioGRID, IntAct32296183 details
PMYT1_HUMANCD79A_HUMANBioGRID, IntAct32296183 details
PMYT1_HUMANZNT8_HUMANBioGRID, IntAct32296183 details
PMYT1_HUMANFA20C_HUMANIntAct22582013 details
PMYT1_HUMANSTEA3_HUMANBioGRID, HPRD12606722 details
PMYT1_HUMANPIN1_HUMANBioGRID, HPRD10504341 9499405 details
PMYT1_HUMANMK08_HUMANBioGRID19204086 details
PMYT1_HUMANMK10_HUMANBioGRID19204086 details
PMYT1_HUMANCCNB1_HUMANBioGRID, HPRD, IntAct, UniProt10373560 23397142 26496610 details
PMYT1_HUMANTGON2_HUMANMINT23241949 details
PMYT1_HUMANPLK1_HUMANHPRD, IntAct12738781 23397142 details
PMYT1_HUMANST7_HUMANBioGRID29395067 details
PMYT1_HUMANBCL2_HUMANHPRD11326318 details