Entity Details

Primary name CATB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07858
EntryNameCATB_HUMAN
FullNameCathepsin B
TaxID9606
Evidenceevidence at protein level
Length339
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesCTSB

GO terms

Show/Hide Table
GOName
GO:0002224 toll-like receptor signaling pathway
GO:0004197 cysteine-type endopeptidase activity
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular anatomical structure
GO:0005764 lysosome
GO:0006508 proteolysis
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016324 apical plasma membrane
GO:0030574 collagen catabolic process
GO:0030855 epithelial cell differentiation
GO:0036021 endolysosome lumen
GO:0042470 melanosome
GO:0042981 regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0043394 proteoglycan binding
GO:0048471 perinuclear region of cytoplasm
GO:0050790 regulation of catalytic activity
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0097067 cellular response to thyroid hormone stimulus
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

Show/Hide Table
Subcellular Location
Apical cell membrane
Lysosome
Melanosome
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR000169 Cysteine peptidase, cysteine active siteSiteActive site
IPR000668 Peptidase C1A, papain C-terminalDomainDomain
IPR012599 Peptidase C1A, propeptideDomainDomain
IPR025660 Cysteine peptidase, histidine active siteSiteActive site
IPR025661 Cysteine peptidase, asparagine active siteSiteActive site
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
148370 OMIMKeratolytic winter erythema (KWE)An autosomal dominant genodermatosis characterized by recurrent episodes of palmoplantar erythema and epidermal peeling presenting seasonal variation. KWE manifests during childhood. Skin lesions may spread to the dorsum of hands and feet and to the interdigital spaces. Lower legs, knees and thighs may also be involved. A less common finding is a slowly migratory, annular erythema that is seen mostly on the extremities. Between flares, the skin can appear unremarkable. Itching can occur, and hyperhidrosis, associated with a pungent odor, is invariably present. Formation of vesicles is rare, whereas keratolysis that causes the formation of dry blisters is regularly seen. Cold weather, moisture, febrile diseases, and physical and mental stress can trigger exacerbations. In severely affected individuals, skin manifestations persist unremittingly. Penetrance of the disease is high, but expressivity is variable, even within the same family. The gene represented in this entry is involved in disease pathogenesis. Tandem duplications in a non-coding genomic region containing an active enhancer element for CTSB result in CTSB abnormal expression with pathological consequences.

Drugs

Show/Hide Table
DrugNameSourceType
DB02108 2-Aminoethanimidic AcidDrugbanksmall molecule
DB02148 3-Amino-4-Oxybenzyl-2-ButanoneDrugbanksmall molecule
DB02685 3-MethylphenylalanineDrugbanksmall molecule
DB02855 N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-ProlineDrugbanksmall molecule
DB03329 2-PyridinethiolDrugbanksmall molecule
DB03588 Diphenylacetic acidDrugbanksmall molecule
DB04126 N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-ButaneDrugbanksmall molecule
DB04579 N-{[(2S,3S)-3-(Ethoxycarbonyl)-2-oxiranyl]carbonyl}-L-threonyl-L-isoleucineDrugbanksmall molecule
DB07160 N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINEDrugbanksmall molecule
DB07219 BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATEDrugbanksmall molecule
DB07223 METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATEDrugbanksmall molecule
DB07224 N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINEDrugbanksmall molecule
DB07225 N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINEDrugbanksmall molecule
DB07231 N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINEDrugbanksmall molecule
DB14962 Trastuzumab deruxtecanDrugbankbiotech

Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
CATB_HUMANBAG6_HUMANBioGRID, HPRD, IntAct16169070 details
CATB_HUMANRGS2_HUMANBioGRID, HPRD, IntAct, MINT16169070 21900206 details
CATB_HUMANATL4_HUMANHPRD, MINT16364318 details
CATB_HUMANAMBP_HUMANBioGRID, MINT16364318 26208400 details
CATB_HUMANSPHK1_HUMANHPRD, MINT15710602 17064696 details
CATB_HUMANCYTA_HUMANBioGRID, HPRD, MINT10353845 14503883 20860624 9585570 details
CATB_HUMANMLH1_HUMANBioGRID, IntAct20706999 details
CATB_HUMANANXA7_HUMANBioGRID, MINT21900206 details
CATB_HUMANCDN1A_HUMANBioGRID, MINT21900206 details
CATB_HUMANF118B_HUMANBioGRID, MINT21900206 details
CATB_HUMANSPY2_HUMANBioGRID, MINT21900206 details
CATB_HUMANSTK11_HUMANBioGRID, MINT25640309 details
CATB_HUMANHSPB2_HUMANbhf-ucl, BioGRID26465331 details
CATB_HUMANBOD1_HUMANIntAct32814053 details
CATB_HUMANCYTB_HUMANBioGRID, HPRD11514663 14503883 26208400 details
CATB_HUMANCYTC_HUMANBioGRID, HPRD11115496 14503883 1996959 22693552 7890620 details
CATB_HUMANS10AA_HUMANBioGRID, HPRD10777578 details
CATB_HUMANANXA2_HUMANBioGRID, HPRD10777578 26208400 details
CATB_HUMANUBQL4_HUMANBioGRID11162551 details
CATB_HUMANSH3K1_HUMANBioGRID16733801 details
CATB_HUMANA4_HUMANBioGRID21832049 details
CATB_HUMANPARP1_HUMANBioGRID11536009 details
CATB_HUMANHNRPD_HUMANBioGRID15231747 details
CATB_HUMANXRN1_HUMANBioGRID15231747 details
CATB_HUMANERPG3_HUMANBioGRID31722399 details
CATB_HUMANERCC6_HUMANBioGRID31722399 details
CATB_HUMANSPIT2_HUMANHPRD16364318 details
CATB_HUMANSRPX2_HUMANHPRD18718938 details
CATB_HUMANDISC1_HUMANIntAct31413325 details
CATB_HUMANEFMT3_HUMANBioGRID23349634 details
CATB_HUMANGCR_HUMANBioGRID28611094 31182584 details
CATB_HUMANMMP9_HUMANBioGRID26208400 details
CATB_HUMANSAMP_HUMANBioGRID26208400 details
CATB_HUMANINS_HUMANBioGRID, HPRD32457219 6351842 details
CATB_HUMANCD151_HUMANBioGRID22495828 details
CATB_HUMANSLPI_HUMANHPRD11435427 details
CATB_HUMANAPOE_HUMANHPRD12057992 details
CATB_HUMANOSTCN_HUMANHPRD9076588 details
CATB_HUMANPGCA_HUMANHPRD1326552 details
CATB_HUMANRENI_HUMANHPRD1597471 2061332 3542996 9928950 details
CATB_HUMANCYTF_HUMANHPRD9632704 9733783 details
CATB_HUMANSPB13_HUMANHPRD10512713 details
CATB_HUMANMARCS_HUMANHPRD9295331 details
CATB_HUMANUROK_HUMANHPRD1900515 details
CATB_HUMANCATD_HUMANHPRD10876156 details
CATB_HUMANCATB_HUMANHPRD1868826 7718586 details
CATB_HUMANIGF1_HUMANHPRD16051222 details
CATB_HUMANA2MG_HUMANHPRD2476070 details