Entity Details

Primary name SYIC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41252
EntryNameSYIC_HUMAN
FullNameIsoleucine--tRNA ligase, cytoplasmic
TaxID9606
Evidenceevidence at protein level
Length1262
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesIARS1

GO terms

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GOName
GO:0000049 tRNA binding
GO:0001649 osteoblast differentiation
GO:0002161 aminoacyl-tRNA editing activity
GO:0004822 isoleucine-tRNA ligase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006418 tRNA aminoacylation for protein translation
GO:0006428 isoleucyl-tRNA aminoacylation
GO:0016020 membrane
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
GO:0051020 GTPase binding
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001412 Aminoacyl-tRNA synthetase, class I, conserved siteSiteConserved site
IPR002300 Aminoacyl-tRNA synthetase, class IaDomainDomain
IPR002301 Isoleucine-tRNA ligaseFamilyFamily
IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domainFamilyHomologous superfamily
IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-bindingFamilyHomologous superfamily
IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-bindingDomainDomain
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily
IPR023586 Isoleucine-tRNA ligase, type 2FamilyFamily
IPR033709 Isoleucyl tRNA synthetase type 2, anticodon-binding domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00167 IsoleucineDrugbanksmall molecule