Entity Details

Primary name ITK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ08881
EntryNameITK_HUMAN
FullNameTyrosine-protein kinase ITK/TSK
TaxID9606
Evidenceevidence at protein level
Length620
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesITK

GO terms

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GOName
GO:0001819 positive regulation of cytokine production
GO:0001865 NK T cell differentiation
GO:0002250 adaptive immune response
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006968 cellular defense response
GO:0007165 signal transduction
GO:0007202 activation of phospholipase C activity
GO:0035556 intracellular signal transduction
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042110 T cell activation
GO:0046629 gamma-delta T cell activation
GO:0046872 metal ion binding
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR001562 Zinc finger, Btk motifSiteConserved site
IPR001849 Pleckstrin homology domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035583 Tyrosine-protein kinase ITK, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR042785 Tyrosine-protein kinase ITK/TSK, catalytic domainDomainDomain

Diseases

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Disease IDSourceNameDescription
613011 OMIMLymphoproliferative syndrome 1 (LPFS1)A rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Inadequate immune response to EBV can have a fatal outcome. Clinical features include splenomegaly, lymphadenopathy, anemia, thrombocytopenia, pancytopenia, recurrent infections. There is an increased risk for lymphoma. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB02010 StaurosporineDrugbanksmall molecule
DB06589 PazopanibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule

Interactions

44 interactions

InteractorPartnerSourcesPublicationsLink
ITK_HUMANLCP2_HUMANBioGRID, DIP, HPRD, MINT10556826 10636929 12190313 15388330 17420479 21725281 details
ITK_HUMANERBB2_HUMANBioGRID, MINT16273093 22973453 details
ITK_HUMANERBB3_HUMANBioGRID, MINT16273093 22973453 details
ITK_HUMANSPR2A_HUMANBioGRID, MINT18155796 details
ITK_HUMANTNFL6_HUMANBioGRID, IntAct19807924 details
ITK_HUMANABI1_HUMANMINT20598684 details
ITK_HUMANNEMO_HUMANBioGRID, IntAct20098747 details
ITK_HUMANGAB1_HUMANBioGRID, IntAct24728074 details
ITK_HUMANMET_HUMANBioGRID, IntAct24728074 details
ITK_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 31980649 details
ITK_HUMANWASP_HUMANbhf-ucl, BioGRID, HPRD8810341 8892607 details
ITK_HUMANADA15_HUMANUniProt25825872 details
ITK_HUMANIMA1_HUMANBioGRID, HPRD11581171 details
ITK_HUMANSOCS1_HUMANBioGRID, HPRD10022833 29991678 details
ITK_HUMANPPIA_HUMANBioGRID, HPRD11830645 details
ITK_HUMANLAT_HUMANBioGRID, HPRD10506192 12186560 details
ITK_HUMANPLCG1_HUMANBioGRID, HPRD10586033 12163161 details
ITK_HUMANFYN_HUMANBioGRID, HPRD10636929 8810341 details
ITK_HUMANSRC_HUMANBioGRID10636929 details
ITK_HUMANGRB2_HUMANBioGRID, HPRD10636929 8985255 details
ITK_HUMANKHDR1_HUMANBioGRID, HPRD12163161 22745667 8810341 8985255 details
ITK_HUMANITK_HUMANBioGRID, HPRD12163161 17192257 7567982 9820515 details
ITK_HUMANHNRPK_HUMANBioGRID, HPRD8810341 details
ITK_HUMANCBL_HUMANBioGRID, HPRD8810341 details
ITK_HUMANFGFR1_HUMANBioGRID22974441 details
ITK_HUMANDOK1_HUMANBioGRID22974441 details
ITK_HUMANSMUF1_HUMANBioGRID20804422 details
ITK_HUMANERBB4_HUMANBioGRID22973453 details
ITK_HUMANSH22A_HUMANHPRD10587356 details
ITK_HUMANG3BP1_HUMANMINT15743820 details
ITK_HUMANHS90B_HUMANBioGRID, IntAct22939624 28514442 details
ITK_HUMANADA10_HUMANUniProt25036101 details
ITK_HUMANCD2_HUMANBioGRID9677430 details
ITK_HUMANIBTK_HUMANBioGRID18596081 details
ITK_HUMANHS90A_HUMANBioGRID22939624 details
ITK_HUMANP85A_HUMANBioGRID9820515 details
ITK_HUMANCD28_HUMANHPRD10586033 15144186 8992971 details
ITK_HUMANBMX_HUMANHPRD12573241 details
ITK_HUMANBTK_HUMANHPRD11598012 12445832 12573241 8629002 8630736 details
ITK_HUMANBLNK_HUMANHPRD10556826 details
ITK_HUMANSMAD4_HUMANHPRD15761153 details
ITK_HUMANTGFR1_HUMANHPRD15761153 details
ITK_HUMANPLCG2_HUMANHPRD15184383 details
ITK_HUMANLCK_HUMANHPRD15144186 9312162 details