Entity Details

Primary name MYLK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15746
EntryNameMYLK_HUMAN
FullNameMyosin light chain kinase, smooth muscle
TaxID9606
Evidenceevidence at protein level
Length1914
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesMYLK

GO terms

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GOName
GO:0001725 stress fiber
GO:0003779 actin binding
GO:0004672 protein kinase activity
GO:0004687 myosin light chain kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006936 muscle contraction
GO:0006939 smooth muscle contraction
GO:0014820 tonic smooth muscle contraction
GO:0015629 actin cytoskeleton
GO:0030027 lamellipodium
GO:0030335 positive regulation of cell migration
GO:0032060 bleb assembly
GO:0032154 cleavage furrow
GO:0046872 metal ion binding
GO:0051928 positive regulation of calcium ion transport
GO:0060414 aorta smooth muscle tissue morphogenesis
GO:0071476 cellular hypotonic response
GO:0090303 positive regulation of wound healing

Subcellular Location

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Subcellular Location
Cell projection
Cleavage furrow
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015725 Myosin Light Chain Kinase 1, Kinase domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule