Entity Details

Primary name HPSE2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8WWQ2
EntryNameHPSE2_HUMAN
FullNameInactive heparanase-2
TaxID9606
Evidenceevidence at protein level
Length592
SequenceStatuscomplete
DateCreated2005-10-25
DateModified2021-06-02

Ontological Relatives

GenesHPSE2

GO terms

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GOName
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0006027 glycosaminoglycan catabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0030198 extracellular matrix organization
GO:0030305 heparanase activity
GO:0031012 extracellular matrix
GO:0043395 heparan sulfate proteoglycan binding

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR005199 Glycoside hydrolase, family 79FamilyFamily
IPR017853 Glycoside hydrolase superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
236730 OMIMUrofacial syndrome 1 (UFS1)A rare autosomal recessive disorder characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure. The disease is caused by variants affecting the gene represented in this entry.

Interactions

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