Entity Details

Primary name PITX2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99697
EntryNamePITX2_HUMAN
FullNamePituitary homeobox 2
TaxID9606
Evidenceevidence at protein level
Length317
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesPITX2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007368 determination of left/right symmetry
GO:0008134 transcription factor binding
GO:0009653 anatomical structure morphogenesis
GO:0035315 hair cell differentiation
GO:0035993 deltoid tuberosity development
GO:0042476 odontogenesis
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043010 camera-type eye development
GO:0043021 ribonucleoprotein complex binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048536 spleen development
GO:0051219 phosphoprotein binding
GO:0060126 somatotropin secreting cell differentiation
GO:0060127 prolactin secreting cell differentiation
GO:0060971 embryonic heart tube left/right pattern formation
GO:0061072 iris morphogenesis
GO:0061325 cell proliferation involved in outflow tract morphogenesis
GO:0070986 left/right axis specification
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR003654 OAR domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR016233 Homeobox protein Pitx/unc30FamilyFamily
IPR017970 Homeobox, conserved siteSiteConserved site

Diseases

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Interactions

55 interactions

InteractorPartnerSourcesPublicationsLink
PITX2_HUMANMEF2A_HUMANbhf-ucl15466416 details
PITX2_HUMANPITX2_HUMANbhf-ucl, BioGRID, HPRD11763998 12612071 15466416 9685346 details
PITX2_HUMANRBPMS_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANKRT34_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANTLE5_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANTBX22_HUMANIntAct32296183 details
PITX2_HUMANANR10_HUMANIntAct32296183 details
PITX2_HUMANSMUG1_HUMANIntAct32296183 details
PITX2_HUMANDDT4L_HUMANIntAct32296183 details
PITX2_HUMANTEX37_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANTRIB3_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANOBF1_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANPFD5_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANWWOX_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANUFSP1_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANHXA1_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANKRA61_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANKR197_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANTRAF1_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANDYLT1_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANPSB4_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANTINAL_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANHEY1_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANVGLL3_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANKR195_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANKR151_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANMS18B_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANKRA33_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANDAZP2_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANKRA71_HUMANBioGRID, IntAct32296183 details
PITX2_HUMANTRI25_HUMANBioGRID, IntAct16884686 20211142 details
PITX2_HUMANZNHI3_HUMANBioGRID, IntAct20211142 details
PITX2_HUMANHERC5_HUMANBioGRID16884686 details
PITX2_HUMANLEF1_HUMANBioGRID, HPRD15728254 details
PITX2_HUMANATN1_HUMANBioGRID32296183 details
PITX2_HUMANZNF34_HUMANBioGRID32296183 details
PITX2_HUMANFOXC1_HUMANIntAct16449236 details
PITX2_HUMANYBOX1_HUMANMINT19174163 details
PITX2_HUMANCTNB1_HUMANBioGRID, HPRD, IntAct, MINT12464179 15728254 19174163 25241761 details
PITX2_HUMANRFC2_HUMANIntAct20195357 details
PITX2_HUMANGP158_HUMANIntAct20195357 details
PITX2_HUMANKAPCB_HUMANIntAct20195357 details
PITX2_HUMANCDC37_HUMANIntAct22939624 details
PITX2_HUMANHDAC1_HUMANBioGRID, HPRD12464179 details
PITX2_HUMANSMAD3_HUMANBioGRID18339718 details
PITX2_HUMANWDR5_HUMANBioGRID21531708 details
PITX2_HUMANWNT2_HUMANBioGRID23250740 details
PITX2_HUMANWNT5A_HUMANBioGRID23250740 details
PITX2_HUMANWNT9A_HUMANBioGRID23250740 details
PITX2_HUMANWNT6_HUMANBioGRID23250740 details
PITX2_HUMANWNT2B_HUMANBioGRID23250740 details
PITX2_HUMANPROP1_HUMANHPRD9685346 details
PITX2_HUMANPDLI1_HUMANHPRD12464179 details
PITX2_HUMANKAT5_HUMANHPRD12464179 details