Entity Details

Primary name DCMC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95822
EntryNameDCMC_HUMAN
FullNameMalonyl-CoA decarboxylase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length493
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesMLYCD

GO terms

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GOName
GO:0002931 response to ischemia
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0006085 acetyl-CoA biosynthetic process
GO:0006633 fatty acid biosynthetic process
GO:0006637 acyl-CoA metabolic process
GO:0008104 protein localization
GO:0010906 regulation of glucose metabolic process
GO:0019395 fatty acid oxidation
GO:0031998 regulation of fatty acid beta-oxidation
GO:0042802 identical protein binding
GO:0046321 positive regulation of fatty acid oxidation
GO:0050080 malonyl-CoA decarboxylase activity
GO:2001294 malonyl-CoA catabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion matrix
Peroxisome
Peroxisome matrix

Domains

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DomainNameCategoryType
IPR007956 Malonyl-CoA decarboxylase, C-terminalDomainDomain
IPR035372 Malonyl-CoA decarboxylase, N-terminalDomainDomain
IPR038351 Malonyl-CoA decarboxylase, N-terminal domain superfamilyFamilyHomologous superfamily
IPR038917 Malonyl-CoA decarboxylaseFamilyFamily
IPR042303 Malonyl-CoA decarboxylase, C-terminal catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
248360 OMIMMalonyl-CoA decarboxylase deficiency (MLYCD deficiency)Autosomal recessive disease characterized by abdominal pain, chronic constipation, episodic vomiting, metabolic acidosis and malonic aciduria. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions