Entity Details - PICKLE: A Protein InteraCtion KnowLedgebasE

Primary name	IL12B_HUMAN
Entity type	UniProt
Source	Source Link

Details

Accession	P29460
EntryName	IL12B_HUMAN
FullName	Interleukin-12 subunit beta
TaxID	9606
Evidence	evidence at protein level
Length	328
SequenceStatus	complete
DateCreated	1993-04-01
DateModified	2021-06-02

Ontological Relatives

Genes

IL12B

GO terms

Show/Hide Table

GO	Name
GO:0001817	regulation of cytokine production
GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002230	positive regulation of defense response to virus by host
GO:0002323	natural killer cell activation involved in immune response
GO:0002827	positive regulation of T-helper 1 type immune response
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002862	negative regulation of inflammatory response to antigenic stimulus
GO:0004896	cytokine receptor activity
GO:0005125	cytokine activity
GO:0005143	interleukin-12 receptor binding
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0005829	cytosol
GO:0008283	cell population proliferation
GO:0009897	external side of plasma membrane
GO:0010224	response to UV-B
GO:0010536	positive regulation of activation of Janus kinase activity
GO:0016477	cell migration
GO:0019221	cytokine-mediated signaling pathway
GO:0019233	sensory perception of pain
GO:0019953	sexual reproduction
GO:0019955	cytokine binding
GO:0030101	natural killer cell activation
GO:0031906	late endosome lumen
GO:0032693	negative regulation of interleukin-10 production
GO:0032700	negative regulation of interleukin-17 production
GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729	positive regulation of interferon-gamma production
GO:0032733	positive regulation of interleukin-10 production
GO:0032735	positive regulation of interleukin-12 production
GO:0032740	positive regulation of interleukin-17 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0032816	positive regulation of natural killer cell activation
GO:0032819	positive regulation of natural killer cell proliferation
GO:0032946	positive regulation of mononuclear cell proliferation
GO:0034105	positive regulation of tissue remodeling
GO:0034393	positive regulation of smooth muscle cell apoptotic process
GO:0035722	interleukin-12-mediated signaling pathway
GO:0038155	interleukin-23-mediated signaling pathway
GO:0042088	T-helper 1 type immune response
GO:0042093	T-helper cell differentiation
GO:0042102	positive regulation of T cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0042164	interleukin-12 alpha subunit binding
GO:0042509	regulation of tyrosine phosphorylation of STAT protein
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802	identical protein binding
GO:0042832	defense response to protozoan
GO:0043235	receptor complex
GO:0043382	positive regulation of memory T cell differentiation
GO:0043514	interleukin-12 complex
GO:0044877	protein-containing complex binding
GO:0045672	positive regulation of osteoclast differentiation
GO:0045785	positive regulation of cell adhesion
GO:0046982	protein heterodimerization activity
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050671	positive regulation of lymphocyte proliferation
GO:0050709	negative regulation of protein secretion
GO:0050729	positive regulation of inflammatory response
GO:0050829	defense response to Gram-negative bacterium
GO:0051135	positive regulation of NK T cell activation
GO:0051142	positive regulation of NK T cell proliferation
GO:0051607	defense response to virus
GO:0070743	interleukin-23 complex
GO:0071222	cellular response to lipopolysaccharide
GO:0071346	cellular response to interferon-gamma
GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway
GO:1901224	positive regulation of NIK/NF-kappaB signaling
GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:2000318	positive regulation of T-helper 17 type immune response
GO:2000330	positive regulation of T-helper 17 cell lineage commitment

Subcellular Location

Show/Hide Table

Subcellular Location
Secreted

Domains

Show/Hide Table

Domain	Name	Category	Type
IPR003530	Long hematopoietin receptor, soluble alpha chain, conserved site	Site	Conserved site
IPR003598	Immunoglobulin subtype 2	Domain	Domain
IPR003961	Fibronectin type III	Domain	Domain
IPR007110	Immunoglobulin-like domain	Domain	Domain
IPR013783	Immunoglobulin-like fold	Family	Homologous superfamily
IPR015528	Interleukin-12 beta	Family	Family
IPR019482	Interleukin-12 beta, central domain	Domain	Domain
IPR036116	Fibronectin type III superfamily	Family	Homologous superfamily
IPR036179	Immunoglobulin-like domain superfamily	Family	Homologous superfamily

Diseases

Show/Hide Table

Disease ID	Source	Name	Description
614890	OMIM	Immunodeficiency 29 (IMD29)	A form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. IMD29 is characterized by undetectable IL12B secretion from leukocytes. Affected individuals generally present with BCG disease after vaccination in childhood, and at least half also have Salmonella infection. Disease phenotype is relatively mild, and patients have a good prognosis. The disease is caused by variants affecting the gene represented in this entry.
612599	OMIM	Psoriasis 11 (PSORS11)	A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

Show/Hide Table

Drug	Name	Source	Type
DB02763	5-Mercapto-2-Nitro-Benzoic Acid	Drugbank	small molecule
DB05459	Briakinumab	Drugbank	biotech
DB05679	Ustekinumab	Drugbank	biotech
DB05848	humanized SMART Anti-IL-12 Antibody	Drugbank	biotech
DB06083	Tapinarof	Drugbank	small molecule
DB14004	Tildrakizumab	Drugbank	biotech
DB14762	Risankizumab	Drugbank	biotech

Interactions

6 interactions

Interactor	Partner	Sources	Publications	Link
IL12B_HUMAN	IL12A_HUMAN	BioGRID, HPRD, IntAct	10899108 7527811	details
IL12B_HUMAN	IL23A_HUMAN	BioGRID, I2D, IntAct	11114383 12023369 18680750 29997244	details
IL12B_HUMAN	IL12B_HUMAN	HPRD, IntAct	7527811	details
IL12B_HUMAN	I12R1_HUMAN	HPRD, IntAct	11114383 7527811 7843232	details
IL12B_HUMAN	ERP44_HUMAN	BioGRID	16467190	details
IL12B_HUMAN	I12R2_HUMAN	HPRD	11940489	details