Entity Details

Primary name ADCY8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP40145
EntryNameADCY8_HUMAN
FullNameAdenylate cyclase type 8
TaxID9606
Evidenceevidence at protein level
Length1251
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesADCY8

GO terms

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GOName
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003091 renal water homeostasis
GO:0003779 actin binding
GO:0004016 adenylate cyclase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0005905 clathrin-coated pit
GO:0006171 cAMP biosynthetic process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007611 learning or memory
GO:0007613 memory
GO:0007616 long-term memory
GO:0007626 locomotory behavior
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity
GO:0010255 glucose mediated signaling pathway
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0030665 clathrin-coated vesicle membrane
GO:0031915 positive regulation of synaptic plasticity
GO:0032793 positive regulation of CREB transcription factor activity
GO:0032809 neuronal cell body membrane
GO:0034199 activation of protein kinase A activity
GO:0035556 intracellular signal transduction
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0038003 G protein-coupled opioid receptor signaling pathway
GO:0042593 glucose homeostasis
GO:0042803 protein homodimerization activity
GO:0044853 plasma membrane raft
GO:0045121 membrane raft
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0048786 presynaptic active zone
GO:0051259 protein complex oligomerization
GO:0051260 protein homooligomerization
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051721 protein phosphatase 2A binding
GO:0060076 excitatory synapse
GO:0071277 cellular response to calcium ion
GO:0071315 cellular response to morphine
GO:0071333 cellular response to glucose stimulus
GO:0071377 cellular response to glucagon stimulus
GO:0080135 regulation of cellular response to stress
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:0098978 glutamatergic synapse
GO:0099056 integral component of presynaptic membrane
GO:0150076 neuroinflammatory response
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1900454 positive regulation of long-term synaptic depression
GO:1904322 cellular response to forskolin

Subcellular Location

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Subcellular Location
Apical cell membrane
Basolateral cell membrane
Cell junction
Cell membrane
Cell projection
Cytoplasmic vesicle
Membrane
Membrane raft

Domains

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DomainNameCategoryType
IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclaseDomainDomain
IPR009398 Adenylate cyclase, conserved domainDomainDomain
IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved siteSiteConserved site
IPR029787 Nucleotide cyclaseFamilyHomologous superfamily
IPR030672 Adenylate cyclaseFamilyFamily
IPR032628 Adenylate cyclase, N-terminalDomainDomain

Diseases

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Interactions

4 interactions