Entity Details

Primary name DYN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP50570
EntryNameDYN2_HUMAN
FullNameDynamin-2
TaxID9606
Evidenceevidence at protein level
Length870
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesDNM2

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000139 Golgi membrane
GO:0000266 mitochondrial fission
GO:0001891 phagocytic cup
GO:0002031 G protein-coupled receptor internalization
GO:0003374 dynamin family protein polymerization involved in mitochondrial fission
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0005925 focal adhesion
GO:0006355 regulation of transcription, DNA-templated
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006893 Golgi to plasma membrane transport
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0006909 phagocytosis
GO:0007165 signal transduction
GO:0007283 spermatogenesis
GO:0008017 microtubule binding
GO:0009416 response to light stimulus
GO:0010592 positive regulation of lamellipodium assembly
GO:0014069 postsynaptic density
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane
GO:0017124 SH3 domain binding
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030027 lamellipodium
GO:0030424 axon
GO:0030426 growth cone
GO:0030496 midbody
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030516 regulation of axon extension
GO:0030666 endocytic vesicle membrane
GO:0030670 phagocytic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0031623 receptor internalization
GO:0031749 D2 dopamine receptor binding
GO:0031966 mitochondrial membrane
GO:0032587 ruffle membrane
GO:0032991 protein-containing complex
GO:0033572 transferrin transport
GO:0035020 regulation of Rac protein signal transduction
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding
GO:0042220 response to cocaine
GO:0043065 positive regulation of apoptotic process
GO:0044327 dendritic spine head
GO:0044351 macropinocytosis
GO:0044877 protein-containing complex binding
GO:0045211 postsynaptic membrane
GO:0045334 clathrin-coated endocytic vesicle
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048471 perinuclear region of cytoplasm
GO:0048489 synaptic vesicle transport
GO:0048812 neuron projection morphogenesis
GO:0050699 WW domain binding
GO:0050766 positive regulation of phagocytosis
GO:0050803 regulation of synapse structure or activity
GO:0050998 nitric-oxide synthase binding
GO:0050999 regulation of nitric-oxide synthase activity
GO:0061024 membrane organization
GO:0061025 membrane fusion
GO:0070062 extracellular exosome
GO:0071245 cellular response to carbon monoxide
GO:0071481 cellular response to X-ray
GO:0071732 cellular response to nitric oxide
GO:0098793 presynapse
GO:0098844 postsynaptic endocytic zone membrane
GO:0098884 postsynaptic neurotransmitter receptor internalization
GO:0098978 glutamatergic synapse
GO:0099092 postsynaptic density, intracellular component
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1902856 negative regulation of non-motile cilium assembly
GO:1903351 cellular response to dopamine
GO:1903358 regulation of Golgi organization
GO:1903408 positive regulation of P-type sodium:potassium-exchanging transporter activity
GO:1903526 negative regulation of membrane tubulation
GO:2000370 positive regulation of clathrin-dependent endocytosis

Subcellular Location

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Subcellular Location
Cell junction
Cell projection
Cytoplasm
Cytoplasmic vesicle
Membrane
Midbody

Domains

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DomainNameCategoryType
IPR000375 Dynamin stalk domainDomainDomain
IPR001401 Dynamin, GTPase domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR003130 Dynamin GTPase effectorDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR019762 Dynamin, GTPase region, conserved siteSiteConserved site
IPR020850 GTPase effector domainDomainDomain
IPR022812 DynaminFamilyFamily
IPR027188 Dynamin-2FamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030381 Dynamin-type guanine nucleotide-binding (G) domainDomainDomain

Diseases

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Disease IDSourceNameDescription
606482 OMIMCharcot-Marie-Tooth disease, dominant, intermediate type, B (CMTDIB)A form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. The dominant intermediate type B is characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. The disease is caused by variants affecting the gene represented in this entry.
606482 OMIMCharcot-Marie-Tooth disease, dominant, intermediate type, B (CMTDIB)A form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. The dominant intermediate type B is characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. The disease is caused by variants affecting the gene represented in this entry.
615368 OMIMLethal congenital contracture syndrome 5 (LCCS5)A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy and congenital non-progressive joint contractures. The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. The disease is caused by variants affecting the gene represented in this entry.
160150 OMIMMyopathy, centronuclear, 1 (CNM1)A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. The disease is caused by variants affecting the gene represented in this entry.

Interactions

214 interactions

InteractorPartnerSourcesPublicationsLink
DYN2_HUMANSH3G1_HUMANMINT10542231 details
DYN2_HUMANAMPH_HUMANBioGRID, HPRD, MINT10542231 15834155 16696976 details
DYN2_HUMANMPH6_HUMANHPRD, IntAct15231747 details
DYN2_HUMANSNX9_HUMANBioGRID, HPRD, IntAct, MINT12952949 15299020 15703209 18388313 27107012 28514442 details
DYN2_HUMANSRC_HUMANBioGRID, HPRD, MINT15834155 21411625 details
DYN2_HUMANGRB2_HUMANBioGRID, HPRD, IntAct, MINT15834155 16696976 19380743 21706016 21988832 27107012 28514442 31980649 details
DYN2_HUMANSH3G2_HUMANBioGRID, MINT15834155 16696976 17257598 details
DYN2_HUMANITSN1_HUMANBioGRID, HPRD, MINT15834155 16696976 21900206 details
DYN2_HUMANDX39B_HUMANBioGRID, HPRD, IntAct16169070 details
DYN2_HUMANZFAN6_HUMANHPRD, IntAct16169070 details
DYN2_HUMANEIF3L_HUMANHPRD, IntAct16169070 details
DYN2_HUMANPPIB_HUMANHPRD, IntAct16169070 details
DYN2_HUMANFNBP1_HUMANBioGRID, UniProt15252009 16418535 details
DYN2_HUMANABL1_HUMANIntAct17474147 details
DYN2_HUMANCRK_HUMANIntAct17474147 details
DYN2_HUMANSRC8_HUMANBioGRID, HPRD, MINT12419186 16636290 details
DYN2_HUMANATX3_HUMANBioGRID, IntAct, MINT21900206 32814053 details
DYN2_HUMANCC90B_HUMANBioGRID, MINT21900206 details
DYN2_HUMANTCPH_HUMANBioGRID, MINT21900206 details
DYN2_HUMANDYN1_HUMANBioGRID, MINT21900206 details
DYN2_HUMANDC1I1_HUMANBioGRID, MINT21900206 details
DYN2_HUMANGDF9_HUMANBioGRID, MINT21900206 details
DYN2_HUMANHMGB1_HUMANBioGRID, MINT21900206 details
DYN2_HUMANMA1B1_HUMANBioGRID, MINT21900206 details
DYN2_HUMANRS2_HUMANBioGRID, MINT21900206 details
DYN2_HUMANRWD2B_HUMANBioGRID, MINT21900206 details
DYN2_HUMANTIAM2_HUMANBioGRID, MINT21900206 details
DYN2_HUMANTYK2_HUMANBioGRID, MINT21900206 details
DYN2_HUMANZBT16_HUMANBioGRID, MINT21900206 details
DYN2_HUMANSPY2_HUMANBioGRID, MINT21900206 details
DYN2_HUMANDP13A_HUMANBioGRID, IntAct23414517 details
DYN2_HUMANPYGM_HUMANBioGRID, IntAct23414517 details
DYN2_HUMANSNAPN_HUMANBioGRID, IntAct23414517 details
DYN2_HUMANHD_HUMANIntAct17500595 32814053 details
DYN2_HUMANSNX33_HUMANIntAct, UniProt18353773 32814053 details
DYN2_HUMANDYN2_HUMANBioGRID, IntAct27107012 details
DYN2_HUMANGRAP2_HUMANBioGRID, IntAct27107012 details
DYN2_HUMANNTAQ1_HUMANBioGRID, IntAct27107012 details
DYN2_HUMANGOGA2_HUMANBioGRID, IntAct27107012 details
DYN2_HUMANXIAP_HUMANBioGRID, IntAct27107012 details
DYN2_HUMANUBS3A_HUMANBioGRID, IntAct32296183 details
DYN2_HUMANSC23A_HUMANBioGRID, IntAct32296183 details
DYN2_HUMANRNF8_HUMANBioGRID, IntAct32296183 details
DYN2_HUMANBAG3_HUMANBioGRID, IntAct32296183 details
DYN2_HUMANTRAF4_HUMANBioGRID, IntAct32296183 32814053 details
DYN2_HUMANSYQ_HUMANBioGRID, IntAct32296183 details
DYN2_HUMANSDCB1_HUMANBioGRID, IntAct32296183 details
DYN2_HUMANAAPK2_HUMANBioGRID, IntAct32296183 details
DYN2_HUMANFAD1_HUMANBioGRID, IntAct32296183 details
DYN2_HUMANNDKB_HUMANDIP24970086 details
DYN2_HUMANPHX2A_HUMANIntAct32814053 details
DYN2_HUMANBOK_HUMANIntAct32814053 details
DYN2_HUMANCISH_HUMANIntAct32814053 details
DYN2_HUMANCSF2_HUMANIntAct32814053 details
DYN2_HUMANEYA3_HUMANIntAct32814053 details
DYN2_HUMANFRIL_HUMANIntAct32814053 details
DYN2_HUMANFYN_HUMANIntAct32814053 details
DYN2_HUMANPRDM1_HUMANIntAct32814053 details
DYN2_HUMANDELE1_HUMANIntAct32814053 details
DYN2_HUMANFEZ2_HUMANIntAct32814053 details
DYN2_HUMANPIWL1_HUMANIntAct32814053 details
DYN2_HUMANP4HA2_HUMANIntAct32814053 details
DYN2_HUMANSTX11_HUMANIntAct32814053 details
DYN2_HUMANNR0B2_HUMANIntAct32814053 details
DYN2_HUMANTAGL2_HUMANIntAct32814053 details
DYN2_HUMANH31_HUMANIntAct32814053 details
DYN2_HUMANFZD4_HUMANIntAct32814053 details
DYN2_HUMANCLPP_HUMANIntAct32814053 details
DYN2_HUMANBRK1_HUMANIntAct32814053 details
DYN2_HUMANTHIO_HUMANIntAct32814053 details
DYN2_HUMANTP53B_HUMANIntAct32814053 details
DYN2_HUMANTGM2_HUMANIntAct32814053 details
DYN2_HUMANTFF2_HUMANIntAct32814053 details
DYN2_HUMANTEF_HUMANIntAct32814053 details
DYN2_HUMANTEAD1_HUMANIntAct32814053 details
DYN2_HUMANSNX2_HUMANIntAct32814053 details
DYN2_HUMANSMN_HUMANIntAct32814053 details
DYN2_HUMANSNF5_HUMANIntAct32814053 details
DYN2_HUMANMK11_HUMANIntAct32814053 details
DYN2_HUMANPIP_HUMANIntAct32814053 details
DYN2_HUMANP85A_HUMANBioGRID, IntAct21996738 32814053 details
DYN2_HUMANOCLN_HUMANIntAct32814053 details
DYN2_HUMANNP1L3_HUMANIntAct32814053 details
DYN2_HUMANMSH5_HUMANIntAct32814053 details
DYN2_HUMANMNDA_HUMANIntAct32814053 details
DYN2_HUMANM3K5_HUMANIntAct32814053 details
DYN2_HUMANLYN_HUMANIntAct32814053 details
DYN2_HUMANHXC4_HUMANIntAct32814053 details
DYN2_HUMANHXK3_HUMANIntAct32814053 details
DYN2_HUMANH2AZ_HUMANIntAct32814053 details
DYN2_HUMANIQEC1_HUMANIntAct32814053 details
DYN2_HUMANCLC2B_HUMANIntAct32814053 details
DYN2_HUMANOPTN_HUMANIntAct32814053 details
DYN2_HUMANPDZ1I_HUMANIntAct32814053 details
DYN2_HUMANMD2L2_HUMANIntAct32814053 details
DYN2_HUMANBAIP2_HUMANIntAct32814053 details
DYN2_HUMANNEBL_HUMANIntAct32814053 details
DYN2_HUMANKAT5_HUMANIntAct32814053 details
DYN2_HUMANTSAP1_HUMANIntAct32814053 details
DYN2_HUMANFBX42_HUMANIntAct32814053 details
DYN2_HUMANTYDP2_HUMANIntAct32814053 details
DYN2_HUMANEVL_HUMANIntAct32814053 details
DYN2_HUMANATLA1_HUMANIntAct32814053 details
DYN2_HUMANSCAPE_HUMANIntAct32814053 details
DYN2_HUMANAAMDC_HUMANIntAct32814053 details
DYN2_HUMANZN638_HUMANIntAct32814053 details
DYN2_HUMANARFG3_HUMANIntAct32814053 details
DYN2_HUMANFBXL4_HUMANIntAct32814053 details
DYN2_HUMANRAB38_HUMANIntAct32814053 details
DYN2_HUMANZDH17_HUMANIntAct32814053 details
DYN2_HUMANPARK7_HUMANIntAct32814053 details
DYN2_HUMANDDX20_HUMANIntAct32814053 details
DYN2_HUMANRASF1_HUMANIntAct32814053 details
DYN2_HUMANWWP2_HUMANIntAct32814053 details
DYN2_HUMANRAB35_HUMANIntAct32814053 details
DYN2_HUMANCBX1_HUMANIntAct32814053 details
DYN2_HUMANMALT1_HUMANIntAct32814053 details
DYN2_HUMANGRAP_HUMANIntAct32814053 details
DYN2_HUMANIQUB_HUMANIntAct32814053 details
DYN2_HUMANASB6_HUMANIntAct32814053 details
DYN2_HUMANRN183_HUMANIntAct32814053 details
DYN2_HUMANSGSM1_HUMANIntAct32814053 details
DYN2_HUMANRAB3I_HUMANIntAct32814053 details
DYN2_HUMANTDIF1_HUMANIntAct32814053 details
DYN2_HUMANS52A3_HUMANIntAct32814053 details
DYN2_HUMANATIF1_HUMANIntAct32814053 details
DYN2_HUMANMOFA1_HUMANIntAct32814053 details
DYN2_HUMANHNRLL_HUMANIntAct32814053 details
DYN2_HUMANZN697_HUMANIntAct32814053 details
DYN2_HUMANTIGD5_HUMANIntAct32814053 details
DYN2_HUMANHUMMR_HUMANIntAct32814053 details
DYN2_HUMANCHMP6_HUMANIntAct32814053 details
DYN2_HUMANTTC23_HUMANIntAct32814053 details
DYN2_HUMANDCR1B_HUMANIntAct32814053 details
DYN2_HUMANAB17C_HUMANIntAct32814053 details
DYN2_HUMANREXO4_HUMANIntAct32814053 details
DYN2_HUMANDAZ3_HUMANIntAct32814053 details
DYN2_HUMANNXT2_HUMANIntAct32814053 details
DYN2_HUMANOTUB1_HUMANIntAct32814053 details
DYN2_HUMANASIC4_HUMANIntAct32814053 details
DYN2_HUMANGLP3L_HUMANIntAct32814053 details
DYN2_HUMANCEP55_HUMANIntAct32814053 details
DYN2_HUMANSPT12_HUMANIntAct32814053 details
DYN2_HUMANVSX2_HUMANIntAct32814053 details
DYN2_HUMANKR197_HUMANIntAct32814053 details
DYN2_HUMANKR195_HUMANIntAct32814053 details
DYN2_HUMANKR133_HUMANIntAct32814053 details
DYN2_HUMANKR191_HUMANIntAct32814053 details
DYN2_HUMANKRA81_HUMANIntAct32814053 details
DYN2_HUMANFOXR1_HUMANIntAct32814053 details
DYN2_HUMANZBT38_HUMANIntAct32814053 details
DYN2_HUMANSPRE2_HUMANIntAct32814053 details
DYN2_HUMANZN366_HUMANIntAct32814053 details
DYN2_HUMANLEG9C_HUMANIntAct32814053 details
DYN2_HUMANCBWD3_HUMANIntAct32814053 details
DYN2_HUMANSTX19_HUMANIntAct32814053 details
DYN2_HUMANFOXA2_HUMANIntAct32814053 details
DYN2_HUMANF111B_HUMANIntAct32814053 details
DYN2_HUMANSHAN1_HUMANBioGRID, HPRD11583995 details
DYN2_HUMANSHAN2_HUMANBioGRID, HPRD11583995 details
DYN2_HUMANCNRG_HUMANBioGRID, HPRD11502744 12624098 details
DYN2_HUMANCIP4_HUMANBioGRID16418535 19041431 details
DYN2_HUMANPPIP1_HUMANBioGRID16418535 19041431 details
DYN2_HUMANITSN2_HUMANBioGRID22558309 32203420 details
DYN2_HUMANA4_HUMANBioGRID21244100 21832049 details
DYN2_HUMANMANEA_HUMANBioGRID16696976 details
DYN2_HUMANPALS2_HUMANBioGRID, HPRD15231747 details
DYN2_HUMANFBP1L_HUMANBioGRID16418535 details
DYN2_HUMANWBP4_HUMANBioGRID16055720 details
DYN2_HUMANBIN1_HUMANBioGRID, HPRD15483625 25350771 details
DYN2_HUMANRHOU_HUMANBioGRID26598620 details
DYN2_HUMANSH3R1_HUMANBioGRID32296183 details
DYN2_HUMANMCAF1_HUMANHPRD15231748 details
DYN2_HUMANHCK_HUMANHPRD, MINT12029088 details
DYN2_HUMANPEF1_HUMANIntAct16169070 details
DYN2_HUMANCRCM_HUMANIntAct17353931 details
DYN2_HUMANMYC_HUMANIntAct17353931 details
DYN2_HUMANAAKB1_HUMANIntAct17353931 details
DYN2_HUMANSRBS1_HUMANMINT19116150 details
DYN2_HUMANMYO1E_HUMANMINT17257598 details
DYN2_HUMANPACN2_HUMANBioGRID, MINT16551695 19041431 details
DYN2_HUMANSH3B4_HUMANMINT16325581 details
DYN2_HUMANSH3K1_HUMANBioGRID, MINT19531213 20711168 26344197 details
DYN2_HUMANRAB7A_HUMANMINT20711168 details
DYN2_HUMANAHI1_HUMANBioGRID, IntAct22623184 details
DYN2_HUMANIDLC_HUMANBioGRID, IntAct27173435 unassigned1312 details
DYN2_HUMANDISC1_HUMANIntAct31413325 details
DYN2_HUMANARX_HUMANMINT21653829 details
DYN2_HUMANFXR1_HUMANMINT21653829 details
DYN2_HUMANFXR2_HUMANMINT21653829 details
DYN2_HUMANSHAN3_HUMANMINT21653829 details
DYN2_HUMANSMCA2_HUMANMINT21653829 details
DYN2_HUMANFER_HUMANBioGRID9722593 details
DYN2_HUMANEPS15_HUMANBioGRID, HPRD11483962 details
DYN2_HUMANPACN1_HUMANBioGRID19041431 details
DYN2_HUMANPACN3_HUMANBioGRID19041431 details
DYN2_HUMANFCSD1_HUMANBioGRID19041431 details
DYN2_HUMANCD2AP_HUMANBioGRID12672817 details
DYN2_HUMANKCNN3_HUMANBioGRID22952906 details
DYN2_HUMANITA4_HUMANBioGRID22623428 details
DYN2_HUMANPTN11_HUMANBioGRID21996738 details
DYN2_HUMANPGFRA_HUMANBioGRID21996738 details
DYN2_HUMANSNX18_HUMANBioGRID26923255 details
DYN2_HUMANVGFR2_HUMANBioGRID, HPRD16049137 details
DYN2_HUMANFAK1_HUMANBioGRID21411625 details
DYN2_HUMANDRD2_HUMANBioGRID14709338 details
DYN2_HUMANPROF1_HUMANHPRD12419186 details
DYN2_HUMANCCR5_HUMANHPRD10477567 details
DYN2_HUMANDYL1_HUMANHPRD14760703 details
DYN2_HUMANSHLB1_HUMANHPRD12456676 16696976 details
DYN2_HUMANCDK1_HUMANHPRD7590285 details
DYN2_HUMANVAV_HUMANHPRD15696170 details
DYN2_HUMANAP2A1_HUMANHPRD16696976 details
DYN2_HUMANAOC1_HUMANHPRD12419186 details