Entity Details

Primary name FOXC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12948
EntryNameFOXC1_HUMAN
FullNameForkhead box protein C1
TaxID9606
Evidenceevidence at protein level
Length553
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesFOXC1

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000792 heterochromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001525 angiogenesis
GO:0001541 ovarian follicle development
GO:0001654 eye development
GO:0001657 ureteric bud development
GO:0001701 in utero embryonic development
GO:0001756 somitogenesis
GO:0001822 kidney development
GO:0001945 lymph vessel development
GO:0001958 endochondral ossification
GO:0001974 blood vessel remodeling
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007219 Notch signaling pathway
GO:0007507 heart development
GO:0008134 transcription factor binding
GO:0008283 cell population proliferation
GO:0008301 DNA binding, bending
GO:0008354 germ cell migration
GO:0009653 anatomical structure morphogenesis
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0014031 mesenchymal cell development
GO:0014032 neural crest cell development
GO:0016477 cell migration
GO:0016525 negative regulation of angiogenesis
GO:0021549 cerebellum development
GO:0030154 cell differentiation
GO:0030199 collagen fibril organization
GO:0030203 glycosaminoglycan metabolic process
GO:0032808 lacrimal gland development
GO:0035050 embryonic heart tube development
GO:0036438 maintenance of lens transparency
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043010 camera-type eye development
GO:0043388 positive regulation of DNA binding
GO:0043565 sequence-specific DNA binding
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046620 regulation of organ growth
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048341 paraxial mesoderm formation
GO:0048844 artery morphogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060038 cardiac muscle cell proliferation
GO:0070098 chemokine-mediated signaling pathway
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0072010 glomerular epithelium development
GO:0097746 blood vessel diameter maintenance
GO:1901491 negative regulation of lymphangiogenesis
GO:1901534 positive regulation of hematopoietic progenitor cell differentiation
GO:1902038 positive regulation of hematopoietic stem cell differentiation
GO:1902257 negative regulation of apoptotic process involved in outflow tract morphogenesis
GO:1904798 positive regulation of core promoter binding
GO:1990841 promoter-specific chromatin binding
GO:1990869 cellular response to chemokine

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001766 Fork head domainDomainDomain
IPR018122 Fork head domain conserved site1SiteConserved site
IPR030456 Fork head domain conserved site 2SiteConserved site
IPR033067 Forkhead box protein C1FamilyFamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table