Entity Details

Primary name DOCK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14185
EntryNameDOCK1_HUMAN
FullNameDedicator of cytokinesis protein 1
TaxID9606
Evidenceevidence at protein level
Length1865
SequenceStatuscomplete
DateCreated2003-07-03
DateModified2021-06-02

Ontological Relatives

GenesDOCK1

GO terms

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GOName
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006911 phagocytosis, engulfment
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007229 integrin-mediated signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007596 blood coagulation
GO:0010634 positive regulation of epithelial cell migration
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0017124 SH3 domain binding
GO:0032045 guanyl-nucleotide exchange factor complex
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR026791 Dedicator of cytokinesisFamilyFamily
IPR027007 C2 DOCK-type domainDomainDomain
IPR027357 DOCKER domainDomainDomain
IPR032376 Dedicator of cytokinesis, N-terminal domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR042455 Dedicator of cytokinesis, N-terminal, subdomain 1FamilyHomologous superfamily
IPR043161 Dedicator of cytokinesis, C-terminal, lobe AFamilyHomologous superfamily
IPR043162 Dedicator of cytokinesis, C-terminal, lobe CFamilyHomologous superfamily

Diseases

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