Entity Details

Primary name BAK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16611
EntryNameBAK_HUMAN
FullNameBcl-2 homologous antagonist/killer
TaxID9606
Evidenceevidence at protein level
Length211
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesBAK1

GO terms

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GOName
GO:0001782 B cell homeostasis
GO:0001783 B cell apoptotic process
GO:0001836 release of cytochrome c from mitochondria
GO:0001974 blood vessel remodeling
GO:0002262 myeloid cell homeostasis
GO:0002352 B cell negative selection
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0007420 brain development
GO:0007568 aging
GO:0008053 mitochondrial fusion
GO:0008283 cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0009620 response to fungus
GO:0010046 response to mycotoxin
GO:0010225 response to UV-C
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0010332 response to gamma radiation
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010629 negative regulation of gene expression
GO:0014070 response to organic cyclic compound
GO:0016032 viral process
GO:0031018 endocrine pancreas development
GO:0031072 heat shock protein binding
GO:0031100 animal organ regeneration
GO:0031307 integral component of mitochondrial outer membrane
GO:0031334 positive regulation of protein-containing complex assembly
GO:0032469 endoplasmic reticulum calcium ion homeostasis
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0034620 cellular response to unfolded protein
GO:0034644 cellular response to UV
GO:0035108 limb morphogenesis
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0044325 transmembrane transporter binding
GO:0044346 fibroblast apoptotic process
GO:0044877 protein-containing complex binding
GO:0045471 response to ethanol
GO:0045862 positive regulation of proteolysis
GO:0046872 metal ion binding
GO:0046902 regulation of mitochondrial membrane permeability
GO:0046930 pore complex
GO:0046982 protein heterodimerization activity
GO:0048597 post-embryonic camera-type eye morphogenesis
GO:0051087 chaperone binding
GO:0051400 BH domain binding
GO:0051726 regulation of cell cycle
GO:0051881 regulation of mitochondrial membrane potential
GO:0060068 vagina development
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070242 thymocyte apoptotic process
GO:0071260 cellular response to mechanical stimulus
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097136 Bcl-2 family protein complex
GO:0097145 BAK complex
GO:0097190 apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097202 activation of cysteine-type endopeptidase activity
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902262 apoptotic process involved in blood vessel morphogenesis
GO:1903896 positive regulation of IRE1-mediated unfolded protein response

Subcellular Location

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Subcellular Location
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR002475 Bcl2-likeFamilyFamily
IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved siteSiteConserved site
IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved siteSiteConserved site
IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved siteSiteConserved site
IPR026298 Bcl-2 familyFamilyFamily
IPR026308 Apoptosis regulator BAKFamilyFamily
IPR036834 Bcl-2-like superfamilyFamilyHomologous superfamily

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
BAK_HUMANBID_HUMANBioGRID, DIP, HPRD, IntAct, Molecular Connections10950869 12624108 23604079 23782464 25408501 details
BAK_HUMANBCL2_HUMANBioGRID, HPRD, IntAct11206074 11728179 14980220 20836993 26004684 32064756 9463381 details
BAK_HUMANB2CL1_HUMANBioGRID, DIP, HPRD, IntAct, MINT, Molecular Connections10085290 11175750 12137781 14596824 15292519 15901672 16189514 17446862 19060904 20836993 22516262 23055042 23680104 26264872 29997244 31467278 31515488 32064756 32296183 32814053 9027312 details
BAK_HUMANMCL1_HUMANBioGRID, DIP, HPRD, I2D, IntAct, MINT, Molecular Connections10579309 10837489 15077116 15637055 15901672 17097560 18040043 19148187 19483105 19968986 20023629 20836993 21132008 21613222 22516262 23680104 26004684 26045051 26186194 27818144 28514442 32296183 details
BAK_HUMANBAK_HUMANBioGRID, HPRD, IntAct, MINT, Molecular Connections10579309 15077116 15901672 16439990 17446862 23782464 details
BAK_HUMANUBE3A_HUMANMINT9881696 details
BAK_HUMANDHB4_HUMANBioGRID, IntAct21988832 details
BAK_HUMANGDIR1_HUMANBioGRID, MINT21900206 details
BAK_HUMANDREB_HUMANBioGRID, MINT21900206 details
BAK_HUMANB2LA1_HUMANBioGRID, HPRD, IntAct10381646 25416956 32296183 details
BAK_HUMANB2CL2_HUMANBioGRID, IntAct10381646 25115399 25416956 32296183 details
BAK_HUMANGRN_HUMANIntAct32814053 details
BAK_HUMANHSPB1_HUMANIntAct32814053 details
BAK_HUMANPSN2_HUMANIntAct32814053 details
BAK_HUMANKIF1B_HUMANIntAct32814053 details
BAK_HUMANATX10_HUMANIntAct32814053 details
BAK_HUMANRNF11_HUMANIntAct32814053 details
BAK_HUMANJPH3_HUMANIntAct32814053 details
BAK_HUMANSPRE1_HUMANIntAct32814053 details
BAK_HUMANSODC_HUMANIntAct32814053 details
BAK_HUMANP53_HUMANBioGRID, HPRD15077116 21712378 25408501 27818144 32064756 details
BAK_HUMANIKBB_HUMANBioGRID8887627 details
BAK_HUMANHERC1_HUMANBioGRID25408501 details
BAK_HUMANBAX_HUMANBioGRID, HPRD, IntAct, MINT11571294 15901672 16439990 17289999 21712378 details
BAK_HUMANVDAC2_HUMANBioGRID, HPRD, IntAct12881569 17353931 details
BAK_HUMANBOP_HUMANIntAct23055042 details
BAK_HUMANCH60_HUMANBioGRID, HPRD12070120 details
BAK_HUMANGIMA5_HUMANBioGRID16509771 details
BAK_HUMANNU5M_HUMANBioGRID25115399 details
BAK_HUMANMK08_HUMANBioGRID19910452 details
BAK_HUMANB2L10_HUMANHPRD9878060 details
BAK_HUMANVDAC1_HUMANHPRD10639121 9843949 details
BAK_HUMANERN1_HUMANHPRD16645094 details