Entity Details

Primary name SREBF1
Entity type gene
Source Source Link

Details

PrimaryID6720
RefseqGeneNG_029029
SymbolSREBF1
Namesterol regulatory element binding transcription factor 1
Chromosome17
Location17p11.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-24
ModificationDate2021-06-19

Ontological Relatives

UniProt IDsSRBP1_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000139 Golgi membrane
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003062 regulation of heart rate by chemical signal
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006629 lipid metabolic process
GO:0007568 aging
GO:0007623 circadian rhythm
GO:0008203 cholesterol metabolic process
GO:0008286 insulin receptor signaling pathway
GO:0008610 lipid biosynthetic process
GO:0009267 cellular response to starvation
GO:0009749 response to glucose
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010876 lipid localization
GO:0010883 regulation of lipid storage
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016021 integral component of membrane
GO:0019216 regulation of lipid metabolic process
GO:0019217 regulation of fatty acid metabolic process
GO:0019901 protein kinase binding
GO:0030324 lung development
GO:0030522 intracellular receptor signaling pathway
GO:0031065 positive regulation of histone deacetylation
GO:0031647 regulation of protein stability
GO:0032094 response to food
GO:0032526 response to retinoic acid
GO:0032570 response to progesterone
GO:0032810 sterol response element binding
GO:0032933 SREBP signaling pathway
GO:0032991 protein-containing complex
GO:0033762 response to glucagon
GO:0042493 response to drug
GO:0042789 mRNA transcription by RNA polymerase II
GO:0044877 protein-containing complex binding
GO:0045444 fat cell differentiation
GO:0045471 response to ethanol
GO:0045540 regulation of cholesterol biosynthetic process
GO:0045542 positive regulation of cholesterol biosynthetic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046676 negative regulation of insulin secretion
GO:0046983 protein dimerization activity
GO:0051591 response to cAMP
GO:0071398 cellular response to fatty acid
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903146 regulation of autophagy of mitochondrion
GO:1903214 regulation of protein targeting to mitochondrion
GO:1990837 sequence-specific double-stranded DNA binding

Diseases

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Interactions

78 interactions

InteractorPartnerSourcesPublicationsLink
SREBF1ATXN1BioGRID, HPRD, IntAct16713569 32814053 details
SREBF1SIRT1BioGRID, UniProt20595232 20817729 details
SREBF1MTNR1BBioGRID, IntAct26514267 details
SREBF1CREBBPBioGRID, DIP, HPRD10235267 16799563 8918891 9651391 9765204 details
SREBF1MED15BioGRID, DIP10235267 11834832 16799563 18385733 20534441 details
SREBF1MED1BioGRID, DIP10235267 16799563 details
SREBF1MED6BioGRID, DIP10235267 11834832 16799563 details
SREBF1CDK8BioGRID, DIP11834832 16799563 details
SREBF1HTTIntAct32814053 details
SREBF1LMNABioGRID, HPRD11929849 19727227 details
SREBF1TWIST2BioGRID, HPRD14654692 details
SREBF1YY1BioGRID, HPRD10224053 details
SREBF1SP1BioGRID, HPRD10224053 10235267 details
SREBF1NR0B1BioGRID, HPRD11713202 details
SREBF1MAPK3BioGRID, HPRD10627507 10915800 details
SREBF1MAPK1BioGRID, HPRD10627507 10915800 details
SREBF1FBXW7BioGRID16054087 19126544 24298052 26759235 27579997 32301540 details
SREBF1KLF13BioGRID16303770 details
SREBF1EP300BioGRID10235267 12640139 14615581 20534441 20817729 details
SREBF1ARBioGRID18245227 details
SREBF1MED23BioGRID10235267 11834832 16799563 details
SREBF1MED7BioGRID10235267 11834832 details
SREBF1MED13BioGRID10235267 11834832 16799563 details
SREBF1MED12BioGRID10235267 11834832 16799563 details
SREBF1MED14BioGRID10235267 11834832 16799563 details
SREBF1MED24BioGRID10235267 11834832 16799563 details
SREBF1MED26BioGRID10235267 11834832 16799563 details
SREBF1HNF4ABioGRID17636037 20817729 details
SREBF1MED25BioGRID11834832 16799563 details
SREBF1MED17BioGRID11834832 16799563 details
SREBF1GSK3BBioGRID19126544 details
SREBF1ZBTB7CBioGRID22331133 details
SREBF1SREBF2BioGRID15798184 details
SREBF1SREBF1BioGRID, HPRD15798184 9634703 details
SREBF1ATXN1LBioGRID16713569 details
SREBF1SMARCD3BioGRID, HPRD14701856 details
SREBF1ID2BioGRID10585876 details
SREBF1ID3BioGRID, HPRD10585876 details
SREBF1PRMT5BioGRID26759235 details
SREBF1PLK1BioGRID27579997 details
SREBF1NR5A2BioGRID17283069 details
SREBF1SMURF1BioGRID32301540 details
SREBF1TP53IntAct22265415 details
SREBF1HSP90AB1IntAct22939624 details
SREBF1MEN1MINT25962847 details
SREBF1UBE2IBioGRID, HPRD12615929 details
SREBF1TRRAPBioGRID20534441 details
SREBF1KAT2ABioGRID20534441 details
SREBF1ATMBioGRID20534441 details
SREBF1GCN1BioGRID20534441 details
SREBF1TADA2BBioGRID20534441 details
SREBF1TADA3BioGRID20534441 details
SREBF1RUVBL2BioGRID20534441 details
SREBF1MED21BioGRID11834832 details
SREBF1ZBTB7ABioGRID18682402 details
SREBF1SCAPBioGRID29097707 9242699 details
SREBF1INSIG1BioGRID12242332 details
SREBF1INSIG2BioGRID12242332 details
SREBF1EGFBioGRID19727227 details
SREBF1HSP90AA1BioGRID22939624 details
SREBF1ERLIN2BioGRID24217618 details
SREBF1KLF5BioGRID18774944 details
SREBF1POLR2ABioGRID29033323 details
SREBF1GOLM1BioGRID29097707 details
SREBF1MDM2BioGRID32332706 details
SREBF1SUMO1HPRD12615929 details
SREBF1ESR1HPRD12021179 details
SREBF1ESR2HPRD12021179 details
SREBF1USF1BioGRID, IntAct19303849 details
SREBF1SORL1BioGRID, IntAct28514442 details
SREBF1PVALBBioGRID, IntAct28514442 details
SREBF1RNF4BioGRID29180619 details
SREBF1H4C1BioGRID30804502 details
SREBF1SPRING1BioGRID32694731 details
SREBF1NCOR1IntAct26120082 details
SREBF1NR1H2IntAct26120082 details
SREBF1NR1H3IntAct26120082 details
SREBF1TRIM25BioGRID29117863 details