Entity Details

Primary name HERC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95714
EntryNameHERC2_HUMAN
FullNameE3 ubiquitin-protein ligase HERC2
TaxID9606
Evidenceevidence at protein level
Length4834
SequenceStatuscomplete
DateCreated2006-04-04
DateModified2021-06-02

Ontological Relatives

GenesHERC2

GO terms

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GOName
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005814 centriole
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006886 intracellular protein transport
GO:0006974 cellular response to DNA damage stimulus
GO:0008270 zinc ion binding
GO:0016020 membrane
GO:0016567 protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0032183 SUMO binding
GO:0061630 ubiquitin protein ligase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000408 Regulator of chromosome condensation, RCC1RepeatRepeat
IPR000433 Zinc finger, ZZ-typeDomainDomain
IPR000569 HECT domainDomainDomain
IPR001199 Cytochrome b5-like heme/steroid binding domainDomainDomain
IPR004939 APC10/DOC domainDomainDomain
IPR006624 Beta-propeller repeat TECPRRepeatRepeat
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein IIFamilyHomologous superfamily
IPR010606 Mib-herc2DomainDomain
IPR014722 Ribosomal protein L2, domain 2FamilyHomologous superfamily
IPR021097 CPH domainDomainDomain
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR036400 Cytochrome b5-like heme/steroid binding domain superfamilyFamilyHomologous superfamily
IPR037252 Mib/herc2 domain superfamilyFamilyHomologous superfamily
IPR037976 HERC2, APC10 domainDomainDomain
IPR041987 HERC2, zinc finger, ZZ-typeDomainDomain
IPR043145 Zinc finger, ZZ-type superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615516 OMIMMental retardation, autosomal recessive 38 (MRT38)A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT38 is characterized by global developmental delay affecting motor, speech, adaptive, and social development. Patients manifest autistic features, aggression, self-injury, impulsivity, and distractibility. The disease is caused by variants affecting the gene represented in this entry.

Interactions

70 interactions

InteractorPartnerSourcesPublicationsLink
HERC2_HUMANDISC1_HUMANIntAct17043677 31413325 details
HERC2_HUMANUBP20_HUMANBioGRID, IntAct19615732 25326330 25355518 25476789 29426014 30279242 details
HERC2_HUMANCDC42_HUMANBioGRID, IntAct20936779 details
HERC2_HUMANP53_HUMANBioGRID, MINT22653443 24722987 27259994 28977907 31665549 details
HERC2_HUMANNCOA4_HUMANBioGRID, IntAct25476789 26436293 28514442 29426014 30279242 details
HERC2_HUMANXPA_HUMANBioGRID, DIP20304803 23178497 details
HERC2_HUMANRNF8_HUMANBioGRID, DIP20023648 22508508 22814251 25305019 26503038 details
HERC2_HUMANC5AR2_HUMANBioGRID, MINT28298427 details
HERC2_HUMANBKRB2_HUMANBioGRID, MINT28298427 details
HERC2_HUMANBRCA1_HUMANBioGRID20631078 25480944 30279242 details
HERC2_HUMANUBE2N_HUMANBioGRID20023648 27259994 details
HERC2_HUMANCALM1_HUMANBioGRID15840729 details
HERC2_HUMANCALM2_HUMANBioGRID15840729 details
HERC2_HUMANCALM3_HUMANBioGRID15840729 details
HERC2_HUMANUBC_HUMANBioGRID22508508 28190767 details
HERC2_HUMANHERC2_HUMANBioGRID22496338 26949039 31582797 details
HERC2_HUMANUB2D3_HUMANBioGRID20631078 details
HERC2_HUMANSTK11_HUMANBioGRID27259994 details
HERC2_HUMANUB2D1_HUMANBioGRID27259994 details
HERC2_HUMANERG_HUMANBioGRID27626314 details
HERC2_HUMANUB2L3_HUMANBioGRID29643511 details
HERC2_HUMANUB2D2_HUMANBioGRID29643511 details
HERC2_HUMANRNF11_HUMANHPRD15231748 details
HERC2_HUMANUBP16_HUMANBioGRID, IntAct19615732 25305019 28514442 30279242 details
HERC2_HUMANKI20A_HUMANBioGRID, IntAct25476789 26496610 details
HERC2_HUMANFBXL5_HUMANBioGRID, IntAct24778179 28514442 30279242 details
HERC2_HUMANNEUL4_HUMANBioGRID, IntAct22261722 25476789 28977907 29426014 29511261 30279242 31665549 details
HERC2_HUMANEME1_HUMANBioGRID, IntAct25476789 29426014 details
HERC2_HUMANFRIH_HUMANBioGRID, IntAct25476789 29426014 details
HERC2_HUMANFRIL_HUMANBioGRID, IntAct25476789 29426014 details
HERC2_HUMANNUDC2_HUMANBioGRID, IntAct25476789 29426014 31427565 details
HERC2_HUMANUBE3A_HUMANBioGRID, IntAct21493713 22645313 25476789 29426014 30257870 30279242 details
HERC2_HUMANKPBB_HUMANBioGRID, IntAct25476789 29426014 details
HERC2_HUMANEIF3M_HUMANBioGRID, IntAct25476789 29426014 30279242 details
HERC2_HUMANEIF3E_HUMANBioGRID, IntAct25476789 29426014 30279242 details
HERC2_HUMANPHKG2_HUMANBioGRID, IntAct25476789 29426014 details
HERC2_HUMANEIF3H_HUMANBioGRID, IntAct25476789 29426014 30279242 details
HERC2_HUMANPMS1_HUMANBioGRID17148452 details
HERC2_HUMANMDC1_HUMANBioGRID20023648 details
HERC2_HUMANRN168_HUMANBioGRID20023648 details
HERC2_HUMANPIAS4_HUMANBioGRID22508508 details
HERC2_HUMANATRIP_HUMANBioGRID21775519 details
HERC2_HUMANCLSPN_HUMANBioGRID21775519 25326330 details
HERC2_HUMANRFA3_HUMANBioGRID22261722 30279242 details
HERC2_HUMANRFA1_HUMANBioGRID22261722 26474068 30279242 31582797 details
HERC2_HUMANPSDE_HUMANBioGRID24743594 details
HERC2_HUMANMUS81_HUMANBioGRID25476789 details
HERC2_HUMANFDFT_HUMANBioGRID25476789 details
HERC2_HUMANHLAA_HUMANBioGRID25476789 details
HERC2_HUMANHM13_HUMANBioGRID25476789 details
HERC2_HUMANBICD2_HUMANBioGRID25476789 28718761 details
HERC2_HUMANZFYV9_HUMANBioGRID25476789 details
HERC2_HUMANCPT1A_HUMANBioGRID25476789 details
HERC2_HUMANAURKB_HUMANBioGRID25476789 details
HERC2_HUMANDAA10_HUMANBioGRID25476789 details
HERC2_HUMANCOPZ1_HUMANBioGRID25476789 details
HERC2_HUMANCOPE_HUMANBioGRID25476789 details
HERC2_HUMANKAP3_HUMANBioGRID25476789 details
HERC2_HUMANNPRL2_HUMANBioGRID25480944 details
HERC2_HUMANLRRK2_HUMANBioGRID26355680 details
HERC2_HUMANATOH1_HUMANBioGRID27542412 details
HERC2_HUMANSIR1_HUMANBioGRID27259994 details
HERC2_HUMANBLM_HUMANBioGRID30279242 details
HERC2_HUMANTOP3A_HUMANBioGRID30279242 details
HERC2_HUMANRMI2_HUMANBioGRID30279242 details
HERC2_HUMANRFA2_HUMANBioGRID30279242 31582797 details
HERC2_HUMANWRN_HUMANBioGRID30279242 details
HERC2_HUMANBARD1_HUMANBioGRID30279242 details
HERC2_HUMANUBP33_HUMANBioGRID31427565 details
HERC2_HUMANMDM2_HUMANBioGRID31665549 details