Entity Details

Primary name I18BP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95998
EntryNameI18BP_HUMAN
FullNameInterleukin-18-binding protein
TaxID9606
Evidenceevidence at protein level
Length194
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesIL18BP

GO terms

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GOName
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0035655 interleukin-18-mediated signaling pathway
GO:0042007 interleukin-18 binding
GO:0042088 T-helper 1 type immune response
GO:0048019 receptor antagonist activity
GO:0070062 extracellular exosome
GO:0071345 cellular response to cytokine stimulus

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR039681 Interleukin-18-binding proteinFamilyFamily

Diseases

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Disease IDSourceNameDescription
618549 OMIMHepatitis, fulminant viral (FVH)An autosomal recessive form of fulminant viral hepatitis, a disease that strikes otherwise healthy individuals during primary infection with common liver-tropic viruses. FVH is characterized by severe liver destruction in the absence of a preexisting liver disorder, leading to encephalopathy within 8 weeks of the onset of the first symptoms. Disease susceptibility may be associated with variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
I18BP_HUMANIL18_HUMANBioGRID, HPRD11907126 details
I18BP_HUMANIL37_HUMANHPRD12381835 details