Entity Details

Primary name MMP7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09237
EntryNameMMP7_HUMAN
FullNameMatrilysin
TaxID9606
Evidenceevidence at protein level
Length267
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesMMP7

GO terms

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GOName
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0007568 aging
GO:0008201 heparin binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0009986 cell surface
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0030574 collagen catabolic process
GO:0031012 extracellular matrix
GO:0031293 membrane protein intracellular domain proteolysis
GO:0031667 response to nutrient levels
GO:0044849 estrous cycle
GO:0060135 maternal process involved in female pregnancy
GO:0070062 extracellular exosome
GO:0071260 cellular response to mechanical stimulus

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001818 Peptidase M10, metallopeptidaseDomainDomain
IPR002477 Peptidoglycan binding-likeDomainDomain
IPR006026 Peptidase, metallopeptidaseDomainDomain
IPR021158 Peptidase M10A, cysteine switch, zinc binding siteSiteBinding site
IPR021190 Peptidase M10AFamilyFamily
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR028707 MatrilysinFamilyFamily
IPR033739 Peptidase M10A, catalytic domainDomainDomain
IPR036365 PGBD-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00786 MarimastatDrugbanksmall molecule
DB08170 (1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDEDrugbanksmall molecule
DB08489 N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDEDrugbanksmall molecule
DB08493 5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACIDDrugbanksmall molecule