Entity Details

Primary name XBP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP17861
EntryNameXBP1_HUMAN
FullNameX-box-binding protein 1
TaxID9606
Evidenceevidence at protein level
Length261
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesXBP1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001525 angiogenesis
GO:0001558 regulation of cell growth
GO:0001889 liver development
GO:0001934 positive regulation of protein phosphorylation
GO:0001935 endothelial cell proliferation
GO:0002020 protease binding
GO:0002639 positive regulation of immunoglobulin production
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006366 transcription by RNA polymerase II
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
GO:0006996 organelle organization
GO:0007517 muscle organ development
GO:0008284 positive regulation of cell population proliferation
GO:0010508 positive regulation of autophagy
GO:0010832 negative regulation of myotube differentiation
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0015031 protein transport
GO:0016021 integral component of membrane
GO:0019901 protein kinase binding
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0030331 estrogen receptor binding
GO:0030335 positive regulation of cell migration
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031062 positive regulation of histone methylation
GO:0031490 chromatin DNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0031647 regulation of protein stability
GO:0031648 protein destabilization
GO:0031670 cellular response to nutrient
GO:0032008 positive regulation of TOR signaling
GO:0032755 positive regulation of interleukin-6 production
GO:0032869 cellular response to insulin stimulus
GO:0034599 cellular response to oxidative stress
GO:0034976 response to endoplasmic reticulum stress
GO:0035356 cellular triglyceride homeostasis
GO:0035470 positive regulation of vascular wound healing
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036498 IRE1-mediated unfolded protein response
GO:0036500 ATF6-mediated unfolded protein response
GO:0042149 cellular response to glucose starvation
GO:0042307 positive regulation of protein import into nucleus
GO:0042632 cholesterol homeostasis
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045579 positive regulation of B cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048666 neuron development
GO:0051897 positive regulation of protein kinase B signaling
GO:0055089 fatty acid homeostasis
GO:0055092 sterol homeostasis
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060612 adipose tissue development
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071073 positive regulation of phospholipid biosynthetic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071230 cellular response to amino acid stimulus
GO:0071332 cellular response to fructose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071353 cellular response to interleukin-4
GO:0071375 cellular response to peptide hormone stimulus
GO:0071498 cellular response to fluid shear stress
GO:0071499 cellular response to laminar fluid shear stress
GO:1900100 positive regulation of plasma cell differentiation
GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1901985 positive regulation of protein acetylation
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:1903489 positive regulation of lactation
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904754 positive regulation of vascular associated smooth muscle cell migration
GO:1990418 response to insulin-like growth factor stimulus
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000347 positive regulation of hepatocyte proliferation
GO:2000353 positive regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum
Endoplasmic reticulum membrane
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR004827 Basic-leucine zipper domainDomainDomain

Diseases

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Disease IDSourceNameDescription
612371 OMIMMajor affective disorder 7 (MAFD7)A major psychiatric disorder that is characterized by severe mood swings, with fluctuation between two abnormal mood states (manic or major depressive episode). Mania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is associated with low mood and decreased motivation and energy. Disease susceptibility may be associated with variants affecting the gene represented in this entry.

Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
XBP1_HUMANXBP1_HUMANBioGRID, HPIDb, HPRD, MINT, UniProt12805554 20102225 23661758 25239945 details
XBP1_HUMANPSA5_HUMANBioGRID, MINT19941857 details
XBP1_HUMANPSA6_HUMANBioGRID, MINT19941857 details
XBP1_HUMANPSA7_HUMANMINT19941857 details
XBP1_HUMANATF6A_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
XBP1_HUMANZHANG_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
XBP1_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
XBP1_HUMANUB2V1_HUMANBioGRID, IntAct32296183 details
XBP1_HUMANATF6B_HUMANBioGRID, UniProt23661758 details
XBP1_HUMANZN440_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANZN580_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANSSX4_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANSRSF1_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANRBL2_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANHDGF_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANH10_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANGLI1_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANNR0B2_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANPHS2_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANH1X_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANFUBP3_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANTRIP4_HUMANBioGRID, IntAct20211142 details
XBP1_HUMANESR1_HUMANBioGRID, HPRD12954762 details
XBP1_HUMANFOS_HUMANBioGRID, HPRD1903538 details
XBP1_HUMANUBC9_HUMANBioGRID23470653 details
XBP1_HUMANMDM2_HUMANBioGRID29057323 details
XBP1_HUMANVIME_HUMANMINT19941857 details
XBP1_HUMANHM13_HUMANBioGRID, MINT25239945 details
XBP1_HUMANRN139_HUMANMINT25239945 details
XBP1_HUMANDERL1_HUMANBioGRID, MINT25239945 details
XBP1_HUMANCALX_HUMANMINT25239945 details
XBP1_HUMANHIF1A_HUMANDIP24670641 details
XBP1_HUMANPSMA8_HUMANBioGRID19941857 details
XBP1_HUMANKAT2B_HUMANBioGRID25426559 details
XBP1_HUMANKAT2A_HUMANBioGRID25426559 details
XBP1_HUMANFBXW7_HUMANBioGRID30783083 details
XBP1_HUMANNFYA_HUMANBioGRID31387940 details
XBP1_HUMANNFYB_HUMANBioGRID31387940 details
XBP1_HUMANNFYC_HUMANBioGRID31387940 details