Entity Details

Primary name F10
Entity type gene
Source Source Link

Details

PrimaryID2159
RefseqGeneNG_009258
SymbolF10
Namecoagulation factor X
Chromosome13
Location13q34
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1988-06-24
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsFA10_HUMAN

GO terms

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GOName
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007596 blood coagulation
GO:0007598 blood coagulation, extrinsic pathway
GO:0030335 positive regulation of cell migration
GO:0031233 intrinsic component of external side of plasma membrane
GO:0051897 positive regulation of protein kinase B signaling
GO:2000264 negative regulation of blood coagulation, extrinsic pathway

Diseases

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Disease IDSourceNameDescription
227600 OMIMFactor X deficiency (FA10D)A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis. The disease is caused by variants affecting the gene represented in this entry.