Entity Details

Primary name ARHG6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15052
EntryNameARHG6_HUMAN
FullNameRho guanine nucleotide exchange factor 6
TaxID9606
Evidenceevidence at protein level
Length776
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesARHGEF6

GO terms

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GOName
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007254 JNK cascade
GO:0030027 lamellipodium
GO:0030032 lamellipodium assembly
GO:0043065 positive regulation of apoptotic process
GO:0051056 regulation of small GTPase mediated signal transduction

Subcellular Location

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Subcellular Location
Cell projection

Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR001715 Calponin homology domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR003096 Smooth muscle protein/calponinFamilyFamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR032409 Rho guanine nucleotide exchange factor, coiled-coil domainDomainDomain
IPR035788 Rho guanine nucleotide exchange factor 6, SH3 domainDomainDomain
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036872 CH domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
ARHG6_HUMANPAK2_HUMANBioGRID, HPRD, IntAct, MINT16374509 28514442 32203420 32296183 details
ARHG6_HUMANADA15_HUMANBioGRID, HPRD, MINT16374509 details
ARHG6_HUMANGIT1_HUMANBioGRID, HPRD, IntAct, MINT10428811 10896954 21900206 28514442 32203420 details
ARHG6_HUMANGASP2_HUMANBioGRID, MINT21900206 details
ARHG6_HUMANPAK1_HUMANBioGRID, HPRD, IntAct, MINT15688026 21900206 23455922 28514442 31980649 32203420 9659915 details
ARHG6_HUMANSH3G3_HUMANBioGRID, MINT21900206 details
ARHG6_HUMANTM108_HUMANBioGRID, MINT21900206 details
ARHG6_HUMANZN580_HUMANBioGRID, MINT21900206 details
ARHG6_HUMANK1C27_HUMANBioGRID, IntAct32296183 details
ARHG6_HUMANGIT2_HUMANBioGRID, IntAct28514442 32203420 32296183 details
ARHG6_HUMANPO6F2_HUMANBioGRID, IntAct32296183 details
ARHG6_HUMANGOGA2_HUMANBioGRID, IntAct32296183 details
ARHG6_HUMANTRI54_HUMANBioGRID, IntAct32296183 details
ARHG6_HUMANIKZF3_HUMANIntAct32296183 details
ARHG6_HUMANRWD2A_HUMANBioGRID, IntAct32296183 details
ARHG6_HUMANTRAF2_HUMANBioGRID, IntAct32296183 details
ARHG6_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
ARHG6_HUMANPNMA1_HUMANBioGRID, IntAct32296183 details
ARHG6_HUMANARHG7_HUMANBioGRID, HPRD, IntAct12499396 15306850 28514442 32203420 details
ARHG6_HUMANSH21A_HUMANDIP, HPRD16983070 details
ARHG6_HUMANARAP3_HUMANBioGRID17314030 details
ARHG6_HUMANSHPS1_HUMANBioGRID19299420 details
ARHG6_HUMANMTG16_HUMANBioGRID32296183 details
ARHG6_HUMANCCD33_HUMANBioGRID32296183 details
ARHG6_HUMANASPP2_HUMANBioGRID32296183 details
ARHG6_HUMANNUTM1_HUMANBioGRID32296183 details
ARHG6_HUMANPARVB_HUMANHPRD12499396 details
ARHG6_HUMANCPNS1_HUMANHPRD15611136 details
ARHG6_HUMANMDM2_HUMANIntAct20195357 details
ARHG6_HUMANNAA10_HUMANIntAct21295525 details
ARHG6_HUMANCDC42_HUMANBioGRID, HPRD, IntAct15306850 15649357 25241761 details
ARHG6_HUMANNHRF2_HUMANBioGRID, IntAct27173435 unassigned1312 details
ARHG6_HUMAN1433G_HUMANHPRD, IntAct15324660 28514442 details
ARHG6_HUMANKPYR_HUMANBioGRID12006652 details
ARHG6_HUMANPRKDC_HUMANBioGRID19918261 details
ARHG6_HUMANARHG6_HUMANBioGRID15306850 details
ARHG6_HUMANTGFR1_HUMANBioGRID, HPRD15761153 details
ARHG6_HUMANTGFR2_HUMANBioGRID, HPRD15761153 details
ARHG6_HUMANRAC1_HUMANBioGRID15306850 19961560 details
ARHG6_HUMANCBL_HUMANBioGRID26177020 details
ARHG6_HUMANPAK3_HUMANHPRD9659915 details
ARHG6_HUMANBMR1B_HUMANHPRD15761153 details
ARHG6_HUMANSMAD1_HUMANHPRD15761153 details
ARHG6_HUMANSMAD2_HUMANHPRD15761153 details
ARHG6_HUMANSMAD3_HUMANHPRD15761153 details
ARHG6_HUMANEPHB2_HUMANHPRD10523848 details