Entity Details

Primary name TNFRSF4
Entity type gene
Source Source Link

Details

PrimaryID7293
RefseqGeneNG_046896
SymbolTNFRSF4
NameTNF receptor superfamily member 4
Chromosome1
Location1p36.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-12-17
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsTNR4_HUMAN

GO terms

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GOName
GO:0001618 virus receptor activity
GO:0002639 positive regulation of immunoglobulin production
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0030890 positive regulation of B cell proliferation
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042098 T cell proliferation
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045892 negative regulation of transcription, DNA-templated

Diseases

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Disease IDSourceNameDescription
615593 OMIMImmunodeficiency 16 (IMD16)An autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency. The disease is caused by variants affecting the gene represented in this entry.