Entity Details

Primary name CDC73_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6P1J9
EntryNameCDC73_HUMAN
FullNameParafibromin
TaxID9606
Evidenceevidence at protein level
Length531
SequenceStatuscomplete
DateCreated2005-12-20
DateModified2021-06-02

Ontological Relatives

GenesCDC73

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000781 chromosome, telomeric region
GO:0000993 RNA polymerase II complex binding
GO:0001558 regulation of cell growth
GO:0001711 endodermal cell fate commitment
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006366 transcription by RNA polymerase II
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006378 mRNA polyadenylation
GO:0007049 cell cycle
GO:0008285 negative regulation of cell population proliferation
GO:0010390 histone monoubiquitination
GO:0016055 Wnt signaling pathway
GO:0016567 protein ubiquitination
GO:0016593 Cdc73/Paf1 complex
GO:0019827 stem cell population maintenance
GO:0030177 positive regulation of Wnt signaling pathway
GO:0031442 positive regulation of mRNA 3'-end processing
GO:0031648 protein destabilization
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0033523 histone H2B ubiquitination
GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex
GO:0043066 negative regulation of apoptotic process
GO:0045638 negative regulation of myeloid cell differentiation
GO:0048147 negative regulation of fibroblast proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0071222 cellular response to lipopolysaccharide
GO:1902808 positive regulation of cell cycle G1/S phase transition
GO:1904837 beta-catenin-TCF complex assembly
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR007852 Cdc73/ParafibrominFamilyFamily
IPR031336 Cell division control protein 73, C-terminalDomainDomain
IPR032041 Paf1 complex subunit Cdc73, N-terminal domainDomainDomain
IPR038103 Cell division control protein 73, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
145001 OMIMHyperparathyroidism 2 with jaw tumors (HRPT2)An autosomal dominant neoplasia syndrome characterized by primary hyperparathyroidism, ossifying fibroma of the maxilla and/or mandible, renal tumor, and uterine tumors. It is associated with increased risk of parathyroid cancer. The disease is caused by variants affecting the gene represented in this entry.
145000 OMIMHyperparathyroidism 1 (HRPT1)An autosomal dominant disorder characterized by hypercalcemia, elevated parathyroid hormone (PTH) levels, and uniglandular or multiglandular parathyroid hyperplasia, adenomas, and carcinomas. The disease is caused by variants affecting the gene represented in this entry.
608266 OMIMParathyroid carcinoma (PRTC)These cancers characteristically result in more profound clinical manifestations of hyperparathyroidism than do parathyroid adenomas, the most frequent cause of primary hyperparathyroidism. Early en bloc resection of the primary tumor is the only curative treatment. The gene represented in this entry is involved in disease pathogenesis.

Interactions

65 interactions

InteractorPartnerSourcesPublicationsLink
CDC73_HUMANVTDB_HUMANBioGRID, HPRD, IntAct16169070 details
CDC73_HUMANKIBRA_HUMANBioGRID, HPRD, IntAct16169070 details
CDC73_HUMANANXA6_HUMANBioGRID, HPRD, IntAct16169070 details
CDC73_HUMANHSP74_HUMANBioGRID, HPRD, IntAct16169070 details
CDC73_HUMANPITH1_HUMANBioGRID, HPRD, IntAct16169070 details
CDC73_HUMANKCNH2_HUMANBioGRID, HPRD, IntAct16169070 details
CDC73_HUMANK1549_HUMANHPRD, IntAct16169070 details
CDC73_HUMANKDIS_HUMANHPRD, IntAct16169070 details
CDC73_HUMANTOM20_HUMANHPRD, IntAct16169070 details
CDC73_HUMANCTNB1_HUMANBioGRID, HPRD, IntAct, MINT16630820 21726809 29774127 details
CDC73_HUMANTCEA1_HUMANBioGRID, IntAct20178742 details
CDC73_HUMANCEP70_HUMANBioGRID, IntAct, MINT21900206 25416956 25910212 32296183 details
CDC73_HUMANDDAH2_HUMANBioGRID, MINT21900206 details
CDC73_HUMANFAF1_HUMANBioGRID, MINT21900206 details
CDC73_HUMANHAP1_HUMANBioGRID, MINT21900206 details
CDC73_HUMANHSF2B_HUMANBioGRID, IntAct, MINT21900206 32296183 details
CDC73_HUMANTIP_HUMANBioGRID, MINT21900206 details
CDC73_HUMANGANP_HUMANBioGRID, MINT21900206 details
CDC73_HUMANFSD2_HUMANBioGRID, IntAct25416956 25910212 31515488 details
CDC73_HUMANHEM1_HUMANBioGRID, IntAct25416956 25910212 31515488 details
CDC73_HUMANGOGA2_HUMANBioGRID, IntAct25416956 25910212 31515488 32296183 details
CDC73_HUMANTFCP2_HUMANBioGRID, IntAct25416956 25910212 details
CDC73_HUMANMTUS2_HUMANBioGRID, IntAct25416956 25910212 32296183 details
CDC73_HUMANKASH5_HUMANBioGRID, IntAct25416956 25910212 details
CDC73_HUMANTSG10_HUMANBioGRID, IntAct25416956 25910212 details
CDC73_HUMANVP37B_HUMANBioGRID, IntAct25416956 details
CDC73_HUMANTRI23_HUMANBioGRID, IntAct32296183 details
CDC73_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
CDC73_HUMANBRE1A_HUMANBioGRID, IntAct22021426 27462432 32296183 details
CDC73_HUMANGG6L9_HUMANBioGRID, IntAct32296183 details
CDC73_HUMANRABE1_HUMANBioGRID, IntAct32296183 details
CDC73_HUMANPTN11_HUMANBioGRID, IntAct21726809 26742426 details
CDC73_HUMANBRE1B_HUMANBioGRID22021426 details
CDC73_HUMANH12_HUMANBioGRID24360965 details
CDC73_HUMANMYC_HUMANBioGRID26687678 30415952 details
CDC73_HUMANITF2_HUMANHPRD, IntAct16630820 details
CDC73_HUMANBCL9_HUMANIntAct16630820 17113272 details
CDC73_HUMANPAF1_HUMANBioGRID, DIP, IntAct, MINT, UniProt15632063 15923622 16024656 18469135 19136632 19410543 20178742 20305087 21726809 22863883 22939629 24981860 26186194 26344197 26496610 27462432 28514442 29774127 details
CDC73_HUMANCTR9_HUMANBioGRID, DIP, IntAct, MINT, UniProt15632063 15923622 16024656 18469135 19136632 20178742 20305087 21726809 22532828 22863883 22939629 24981860 26186194 26344197 26496610 28514442 29774127 details
CDC73_HUMANLEO1_HUMANBioGRID, DIP, IntAct, MINT, UniProt15632063 15923622 16024656 18469135 19136632 20178742 20305087 21726809 22939629 24981860 26186194 26344197 26496610 28514442 29774127 details
CDC73_HUMANRTF1_HUMANBioGRID, IntAct, UniProt15923622 16024656 20178742 details
CDC73_HUMANWDR61_HUMANBioGRID, DIP, IntAct, MINT, UniProt16024656 19136632 20178742 20305087 22451921 24981860 26186194 26344197 26496610 29774127 details
CDC73_HUMANKMT2A_HUMANBioGRID, IntAct20541477 details
CDC73_HUMANRPB1_HUMANBioGRID, DIP, UniProt15632063 15923622 16024656 26659056 details
CDC73_HUMANSPT5H_HUMANBioGRID, IntAct26496610 29395067 details
CDC73_HUMANCSTF2_HUMANBioGRID, DIP19136632 details
CDC73_HUMANCPSF4_HUMANBioGRID, DIP19136632 details
CDC73_HUMANSETB1_HUMANMINT29774127 details
CDC73_HUMANEHMT2_HUMANMINT29774127 details
CDC73_HUMANRBP2_HUMANBioGRID15632063 details
CDC73_HUMANRRAGA_HUMANBioGRID19136632 details
CDC73_HUMANHS90A_HUMANBioGRID20305087 27462432 details
CDC73_HUMANH31_HUMANBioGRID22451921 details
CDC73_HUMANSUV91_HUMANBioGRID21726809 details
CDC73_HUMANBCL9L_HUMANBioGRID17113272 details
CDC73_HUMANDNM3A_HUMANBioGRID21406692 details
CDC73_HUMANDNM3B_HUMANBioGRID21406692 details
CDC73_HUMANH11_HUMANBioGRID24360965 details
CDC73_HUMANTF7L2_HUMANBioGRID16630820 details
CDC73_HUMANH2B2E_HUMANBioGRID27462432 details
CDC73_HUMANH31T_HUMANBioGRID27462432 details
CDC73_HUMANNXF1_HUMANBioGRID29395067 details
CDC73_HUMANMCE1_HUMANBioGRID29395067 details
CDC73_HUMANSMG7_HUMANBioGRID29395067 details
CDC73_HUMANBIN1_HUMANBioGRID31815296 details