Entity Details
| Primary name |
DEN1B_HUMAN |
| Entity type |
UniProt |
| Source |
Source Link |
Details
| Accession | Q6P3S1 |
| EntryName | DEN1B_HUMAN |
| FullName | DENN domain-containing protein 1B |
| TaxID | 9606 |
| Evidence | evidence at protein level |
| Length | 775 |
| SequenceStatus | complete |
| DateCreated | 2007-09-11 |
| DateModified | 2021-06-02 |
Subcellular Location
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| Subcellular Location |
| Cytoplasm |
| Cytoplasmic vesicle |
Domains
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| Domain | Name | Category | Type |
| IPR001194 | cDENN domain | Domain | Domain |
| IPR005112 | dDENN domain | Domain | Domain |
| IPR005113 | uDENN domain | Domain | Domain |
| IPR037516 | Tripartite DENN domain | Domain | Domain |
| IPR040032 | DENN domain-containing protein 1A/1B/1C | Family | Family |
| IPR043153 | DENN domain, C-terminal lobe | Family | Homologous superfamily |
Diseases
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| Disease ID | Source | Name | Description |
| 600807 | OMIM | Asthma (ASTHMA) | The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. Disease susceptibility is associated with variants affecting the gene represented in this entry. Asthma susceptibility is probably caused by decreased TCR down-modulation and recycling in TH2 cells, causing prolonged TCR signaling and increased cytokine production in TH2 lymphocytes (PubMed:26774822). |
Interactions
1 interaction