Entity Details

Primary name APOA5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6Q788
EntryNameAPOA5_HUMAN
FullNameApolipoprotein A-V
TaxID9606
Evidenceevidence at protein level
Length366
SequenceStatuscomplete
DateCreated2005-02-01
DateModified2021-06-02

Ontological Relatives

GenesAPOA5

GO terms

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GOName
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005788 endoplasmic reticulum lumen
GO:0005794 Golgi apparatus
GO:0006641 triglyceride metabolic process
GO:0006695 cholesterol biosynthetic process
GO:0006869 lipid transport
GO:0008047 enzyme activator activity
GO:0008201 heparin binding
GO:0008289 lipid binding
GO:0010873 positive regulation of cholesterol esterification
GO:0010898 positive regulation of triglyceride catabolic process
GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling
GO:0015485 cholesterol binding
GO:0019222 regulation of metabolic process
GO:0019433 triglyceride catabolic process
GO:0019899 enzyme binding
GO:0030300 regulation of intestinal cholesterol absorption
GO:0031210 phosphatidylcholine binding
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034361 very-low-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0034372 very-low-density lipoprotein particle remodeling
GO:0034380 high-density lipoprotein particle assembly
GO:0035473 lipase binding
GO:0042157 lipoprotein metabolic process
GO:0042246 tissue regeneration
GO:0042627 chylomicron
GO:0042632 cholesterol homeostasis
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0046470 phosphatidylcholine metabolic process
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0050750 low-density lipoprotein particle receptor binding
GO:0050996 positive regulation of lipid catabolic process
GO:0051006 positive regulation of lipoprotein lipase activity
GO:0055090 acylglycerol homeostasis
GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0060229 lipase activator activity
GO:0060230 lipoprotein lipase activator activity
GO:0070325 lipoprotein particle receptor binding
GO:0070328 triglyceride homeostasis

Subcellular Location

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Subcellular Location
Early endosome
Golgi apparatus
Late endosome
Secreted

Domains

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DomainNameCategoryType
IPR000074 Apolipoprotein A/EFamilyFamily

Diseases

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Disease IDSourceNameDescription
144650 OMIMHyperlipoproteinemia 5 (HLPP5)Characterized by increased amounts of chylomicrons and very low density lipoprotein (VLDL) and decreased low density lipoprotein (LDL) and high density lipoprotein (HDL) in the plasma after a fast. Numerous conditions cause this phenotype, including insulin-dependent diabetes mellitus, contraceptive steroids, alcohol abuse, and glycogen storage disease type 1A (GSD1A). The disease is caused by variants affecting the gene represented in this entry.
145750 OMIMHypertriglyceridemia, familial (FHTR)A common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis. Disease susceptibility is associated with variants affecting the gene represented in this entry.