Entity Details

Primary name KCNT2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6UVM3
EntryNameKCNT2_HUMAN
FullNamePotassium channel subfamily T member 2
TaxID9606
Evidenceevidence at protein level
Length1135
SequenceStatuscomplete
DateCreated2007-12-04
DateModified2021-06-02

Ontological Relatives

GenesKCNT2

GO terms

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GOName
GO:0005228 intracellular sodium activated potassium channel activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0015271 outward rectifier potassium channel activity
GO:0016021 integral component of membrane
GO:0070089 chloride-activated potassium channel activity
GO:0097623 potassium ion export across plasma membrane

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR003929 Calcium-activated potassium channel BK, alpha subunitDomainDomain
IPR013099 Potassium channel domainDomainDomain
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617771 OMIMDevelopmental and epileptic encephalopathy 57 (DEE57)A form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE57 is an autosomal dominant condition. The disease is caused by variants affecting the gene represented in this entry.

Interactions

0 interactions

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