Entity Details

Primary name GRP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ7LDG7
EntryNameGRP2_HUMAN
FullNameRAS guanyl-releasing protein 2
TaxID9606
Evidenceevidence at protein level
Length609
SequenceStatuscomplete
DateCreated2008-01-15
DateModified2021-06-02

Ontological Relatives

GenesRASGRP2

GO terms

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GOName
GO:0001558 regulation of cell growth
GO:0002250 adaptive immune response
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0007265 Ras protein signal transduction
GO:0008289 lipid binding
GO:0019992 diacylglycerol binding
GO:0032587 ruffle membrane
GO:0043005 neuron projection
GO:0043547 positive regulation of GTPase activity
GO:0045202 synapse
GO:0071277 cellular response to calcium ion

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminalDomainDomain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008937 Ras-like guanine nucleotide exchange factorFamilyFamily
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR023578 Ras guanine nucleotide exchange factor domain superfamilyFamilyHomologous superfamily
IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615888 OMIMBleeding disorder, platelet-type 18 (BDPLT18)A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. The disease is caused by variants affecting the gene represented in this entry.

Interactions

4 interactions