Entity Details

Primary name TRPM8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ7Z2W7
EntryNameTRPM8_HUMAN
FullNameTransient receptor potential cation channel subfamily M member 8
TaxID9606
Evidenceevidence at protein level
Length1104
SequenceStatuscomplete
DateCreated2004-12-21
DateModified2021-06-02

Ontological Relatives

GenesTRPM8

GO terms

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GOName
GO:0005261 cation channel activity
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0009409 response to cold
GO:0009897 external side of plasma membrane
GO:0016048 detection of temperature stimulus
GO:0042802 identical protein binding
GO:0045121 membrane raft
GO:0050955 thermoception
GO:0070588 calcium ion transmembrane transport
GO:0098655 cation transmembrane transport
GO:0099604 ligand-gated calcium channel activity
GO:0120162 positive regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane
Membrane raft

Domains

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DomainNameCategoryType
IPR005821 Ion transport domainDomainDomain
IPR029603 Transient receptor potential cation channel subfamily M member 8FamilyFamily
IPR041491 TRPM, SLOG domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00825 LevomentholDrugbanksmall molecule
DB01744 CamphorDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB11345 (S)-camphorDrugbanksmall molecule
DB11755 TetrahydrocannabivarinDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
TRPM8_HUMANAKAP5_HUMANBioGRID18701070 details