Entity Details

Primary name I2BP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ7Z5L9
EntryNameI2BP2_HUMAN
FullNameInterferon regulatory factor 2-binding protein 2
TaxID9606
Evidenceevidence at protein level
Length587
SequenceStatuscomplete
DateCreated2008-04-08
DateModified2021-06-02

Ontological Relatives

GenesIRF2BP2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0002327 immature B cell differentiation
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR022750 Interferon regulatory factor 2-binding protein 1 & 2, zinc fingerDomainDomain

Diseases

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Disease IDSourceNameDescription
617765 OMIMImmunodeficiency, common variable, 14 (CVID14)A primary immunodeficiency resulting in recurrent sinopulmonary infections since early childhood, and characterized by hypogammaglobulinemia with undetectable IgG and IgA, poor response to vaccination, and decreased levels of switched memory B cells. CVID14 inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.