Entity Details

Primary name FGD2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ7Z6J4
EntryNameFGD2_HUMAN
FullNameFYVE, RhoGEF and PH domain-containing protein 2
TaxID9606
Evidenceevidence at protein level
Length655
SequenceStatuscomplete
DateCreated2005-03-15
DateModified2021-06-02

Ontological Relatives

GenesFGD2

GO terms

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GOName
GO:0001726 ruffle
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0007010 cytoskeleton organization
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008360 regulation of cell shape
GO:0030027 lamellipodium
GO:0030036 actin cytoskeleton organization
GO:0031267 small GTPase binding
GO:0031901 early endosome membrane
GO:0032587 ruffle membrane
GO:0043065 positive regulation of apoptotic process
GO:0043087 regulation of GTPase activity
GO:0043507 positive regulation of JUN kinase activity
GO:0046847 filopodium assembly
GO:0046872 metal ion binding
GO:0051056 regulation of small GTPase mediated signal transduction
GO:1901981 phosphatidylinositol phosphate binding

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Early endosome
Early endosome membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR000306 FYVE zinc fingerDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017455 Zinc finger, FYVE-relatedDomainDomain
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR035941 FGD1-4, C-terminal PH domainDomainDomain
IPR037797 FGD2, N-terminal PH domainDomainDomain

Diseases

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Interactions

6 interactions