Entity Details
| Primary name |
HOGA1_HUMAN |
| Entity type |
UniProt |
| Source |
Source Link |
Details
| Accession | Q86XE5 |
| EntryName | HOGA1_HUMAN |
| FullName | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial |
| TaxID | 9606 |
| Evidence | evidence at protein level |
| Length | 327 |
| SequenceStatus | complete |
| DateCreated | 2007-01-23 |
| DateModified | 2021-06-02 |
Subcellular Location
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| Subcellular Location |
| Mitochondrion |
Domains
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| Domain | Name | Category | Type |
| IPR002220 | DapA-like | Family | Family |
| IPR013785 | Aldolase-type TIM barrel | Family | Homologous superfamily |
| IPR020625 | Schiff base-forming aldolase, active site | Site | Active site |
Diseases
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| Disease ID | Source | Name | Description |
| 613616 | OMIM | Hyperoxaluria primary 3 (HP3) | A disorder phenotypically similar to hyperoxaluria type 1 and type 2. It is characterized by increase in urinary oxalate excretion and mild glycolic aciduria. Clinical manifestations include calcium oxalate urolithiasis, hematuria, pain, and/or urinary tract infection. The disease is caused by variants affecting the gene represented in this entry. |
Interactions
3 interactions