Entity Details

Primary name TCAM2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ86XR7
EntryNameTCAM2_HUMAN
FullNameTIR domain-containing adapter molecule 2
TaxID9606
Evidenceevidence at protein level
Length235
SequenceStatuscomplete
DateCreated2008-02-05
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0001891 phagocytic cup
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0006886 intracellular protein transport
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0007030 Golgi organization
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0010008 endosome membrane
GO:0030134 COPII-coated ER to Golgi transport vesicle
GO:0030667 secretory granule membrane
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035669 TRAM-dependent toll-like receptor 4 signaling pathway
GO:0042995 cell projection
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043312 neutrophil degranulation
GO:0045087 innate immune response
GO:0070266 necroptotic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production
GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production
GO:0097190 apoptotic signaling pathway
GO:2000494 positive regulation of interleukin-18-mediated signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Early endosome membrane
Endoplasmic reticulum
Golgi apparatus
Late endosome membrane

Domains

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DomainNameCategoryType
IPR000157 Toll/interleukin-1 receptor homology (TIR) domainDomainDomain
IPR015720 Transmembrane emp24 domain-containing proteinFamilyFamily
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily

Diseases

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