Entity Details

Primary name PLCZ1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ86YW0
EntryNamePLCZ1_HUMAN
FullName1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
TaxID9606
Evidenceevidence at protein level
Length608
SequenceStatuscomplete
DateCreated2008-09-02
DateModified2021-06-02

Ontological Relatives

GenesPLCZ1

GO terms

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GOName
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0005509 calcium ion binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006816 calcium ion transport
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007275 multicellular organism development
GO:0007343 egg activation
GO:0010314 phosphatidylinositol-5-phosphate binding
GO:0016042 lipid catabolic process
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0043647 inositol phosphate metabolic process
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048471 perinuclear region of cytoplasm
GO:0060470 positive regulation of cytosolic calcium ion concentration involved in egg activation
GO:0061827 sperm head

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000909 Phosphatidylinositol-specific phospholipase C, X domainDomainDomain
IPR001192 Phosphoinositide phospholipase C familyFamilyFamily
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domainDomainDomain
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamilyFamilyHomologous superfamily
IPR028395 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1FamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617214 OMIMSpermatogenic failure 17 (SPGF17)An autosomal recessive infertility disorder due to failure of oocyte activation and fertilization by sperm that otherwise exhibits normal morphology. The disease is caused by variants affecting the gene represented in this entry.

Interactions

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