Entity Details

Primary name AT2L2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IUZ5
EntryNameAT2L2_HUMAN
FullName5-phosphohydroxy-L-lysine phospho-lyase
TaxID9606
Evidenceevidence at protein level
Length450
SequenceStatuscomplete
DateCreated2007-05-15
DateModified2021-06-02

Ontological Relatives

GenesPHYKPL

GO terms

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GOName
GO:0005759 mitochondrial matrix
GO:0006554 lysine catabolic process
GO:0008483 transaminase activity
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0030574 collagen catabolic process
GO:0042802 identical protein binding

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR005814 Aminotransferase class-IIIFamilyFamily
IPR015421 Pyridoxal phosphate-dependent transferase, major domainFamilyHomologous superfamily
IPR015422 Pyridoxal phosphate-dependent transferase, small domainFamilyHomologous superfamily
IPR015424 Pyridoxal phosphate-dependent transferaseFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615011 OMIMPhosphohydroxylysinuria (PHLU)A condition characterized by elevated phosphohydroxylysine in the urine. There is no clinical phenotype associated with this finding other than the urinary metabolites. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule
DB00160 AlanineDrugbanksmall molecule

Interactions

5 interactions