Entity Details

Primary name SCN4B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8IWT1
EntryNameSCN4B_HUMAN
FullNameSodium channel subunit beta-4
TaxID9606
Evidenceevidence at protein level
Length228
SequenceStatuscomplete
DateCreated2005-01-04
DateModified2021-06-02

Ontological Relatives

GenesSCN4B

GO terms

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GOName
GO:0001518 voltage-gated sodium channel complex
GO:0005244 voltage-gated ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0006814 sodium ion transport
GO:0010765 positive regulation of sodium ion transport
GO:0014704 intercalated disc
GO:0017080 sodium channel regulator activity
GO:0031226 intrinsic component of plasma membrane
GO:0035725 sodium ion transmembrane transport
GO:0044325 transmembrane transporter binding
GO:0060048 cardiac muscle contraction
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0086016 AV node cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:2000649 regulation of sodium ion transmembrane transporter activity

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000920 Myelin P0 protein-relatedFamilyFamily
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR044572 Sodium channel subunit beta-4FamilyFamily

Diseases

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Disease IDSourceNameDescription
611819 OMIMLong QT syndrome 10 (LQT10)A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. The disease is caused by variants affecting the gene represented in this entry.
611819 OMIMLong QT syndrome 10 (LQT10)A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00243 RanolazineDrugbanksmall molecule
DB00313 Valproic acidDrugbanksmall molecule
DB00776 OxcarbazepineDrugbanksmall molecule
DB00907 CocaineDrugbanksmall molecule
DB00909 ZonisamideDrugbanksmall molecule
DB05541 BrivaracetamDrugbanksmall molecule
DB13269 Dichlorobenzyl alcoholDrugbanksmall molecule
DB13961 Fish oilDrugbankbiotech

Interactions

4 interactions