Entity Details

Primary name ADAS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00116
EntryNameADAS_HUMAN
FullNameAlkyldihydroxyacetonephosphate synthase, peroxisomal
TaxID9606
Evidenceevidence at protein level
Length658
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesAGPS

GO terms

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GOName
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0008104 protein localization
GO:0008609 alkylglycerone-phosphate synthase activity
GO:0008610 lipid biosynthetic process
GO:0008611 ether lipid biosynthetic process
GO:0016020 membrane
GO:0016491 oxidoreductase activity
GO:0071949 FAD binding

Subcellular Location

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Subcellular Location
Peroxisome
Peroxisome membrane

Domains

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DomainNameCategoryType
IPR004113 FAD-linked oxidase, C-terminalDomainDomain
IPR006094 FAD linked oxidase, N-terminalDomainDomain
IPR016164 FAD-linked oxidase-like, C-terminalFamilyHomologous superfamily
IPR016166 FAD-binding domain, PCMH-typeDomainDomain
IPR016167 FAD-binding, type PCMH, subdomain 1FamilyHomologous superfamily
IPR016169 FAD-binding, type PCMH, subdomain 2FamilyHomologous superfamily
IPR016171 Vanillyl-alcohol oxidase, C-terminal subdomain 2FamilyHomologous superfamily
IPR025650 Alkyldihydroxyacetonephosphate synthaseFamilyFamily
IPR036318 FAD-binding, type PCMH-like superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
600121 OMIMRhizomelic chondrodysplasia punctata 3 (RCDP3)A form of rhizomelic chondrodysplasia punctata, a disease characterized by severely disturbed endochondral bone formation, rhizomelic shortening of femur and humerus, vertebral disorders, dwarfism, cataract, cutaneous lesions, facial dysmorphism, and severe mental retardation with spasticity. The disease is caused by variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
ADAS_HUMANGORS1_HUMANBioGRID, IntAct25416956 31515488 32296183 details
ADAS_HUMANGNPAT_HUMANBioGRID, HPRD10215861 34079125 details