Entity Details

Primary name BIN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00499
EntryNameBIN1_HUMAN
FullNameMyc box-dependent-interacting protein 1
TaxID9606
Evidenceevidence at protein level
Length593
SequenceStatuscomplete
DateCreated2001-07-11
DateModified2021-06-02

Ontological Relatives

GenesBIN1

GO terms

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GOName
GO:0002020 protease binding
GO:0005543 phospholipid binding
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006897 endocytosis
GO:0006997 nucleus organization
GO:0007010 cytoskeleton organization
GO:0008021 synaptic vesicle
GO:0008333 endosome to lysosome transport
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016032 viral process
GO:0019828 aspartic-type endopeptidase inhibitor activity
GO:0030018 Z disc
GO:0030100 regulation of endocytosis
GO:0030276 clathrin binding
GO:0030315 T-tubule
GO:0030424 axon
GO:0030425 dendrite
GO:0030838 positive regulation of actin filament polymerization
GO:0031674 I band
GO:0031982 vesicle
GO:0033268 node of Ranvier
GO:0033292 T-tubule organization
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043194 axon initial segment
GO:0045664 regulation of neuron differentiation
GO:0048156 tau protein binding
GO:0048711 positive regulation of astrocyte differentiation
GO:0051015 actin filament binding
GO:0051087 chaperone binding
GO:0051647 nucleus localization
GO:0060987 lipid tube
GO:0060988 lipid tube assembly
GO:0061024 membrane organization
GO:0070063 RNA polymerase binding
GO:0086091 regulation of heart rate by cardiac conduction
GO:1901380 negative regulation of potassium ion transmembrane transport
GO:1902430 negative regulation of amyloid-beta formation
GO:1902960 negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1903946 negative regulation of ventricular cardiac muscle cell action potential
GO:1904878 negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endosome
Nucleus

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR003005 AmphiphysinFamilyFamily
IPR003023 Amphiphysin 2FamilyFamily
IPR004148 BAR domainDomainDomain
IPR027267 AH/BAR domain superfamilyFamilyHomologous superfamily
IPR035471 Amphiphysin 2, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
255200 OMIMMyopathy, centronuclear, 2 (CNM2)A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. The disease is caused by variants affecting the gene represented in this entry.

Interactions

113 interactions

InteractorPartnerSourcesPublicationsLink
BIN1_HUMANRIN3_HUMANBioGRID, HPRD, IntAct, MINT12972505 32552912 details
BIN1_HUMANSNX4_HUMANBioGRID, HPRD, IntAct, MINT12668730 31413325 details
BIN1_HUMANCUX1_HUMANBioGRID, HPRD, IntAct16169070 details
BIN1_HUMANGRB2_HUMANIntAct17474147 details
BIN1_HUMANDYN1_HUMANBioGRID, HPRD, IntAct16275660 9195986 9280305 details
BIN1_HUMANDLGP4_HUMANBioGRID, HPRD, IntAct16275660 details
BIN1_HUMANXRCC4_HUMANBioGRID, HPRD, IntAct16275660 details
BIN1_HUMANF16P1_HUMANBioGRID, HPRD, IntAct16275660 details
BIN1_HUMANMYC_HUMANBioGRID, HPRD, MINT10380878 11306501 15992821 30253944 31815296 details
BIN1_HUMANDP13A_HUMANBioGRID, IntAct23414517 details
BIN1_HUMANSNAPN_HUMANBioGRID, IntAct23414517 details
BIN1_HUMANTAU_HUMANBioGRID, IntAct, UniProt23399914 25051234 26395440 28755476 details
BIN1_HUMANMTM1_HUMANBioGRID, MINT23917616 details
BIN1_HUMANBIN1_HUMANBioGRID, HPRD, IntAct, MINT10391921 23917616 31413325 details
BIN1_HUMANPE2R4_HUMANBioGRID, MINT28298427 details
BIN1_HUMANSOS1_HUMANBioGRID, HPRD, IntAct32203420 9182529 details
BIN1_HUMANRFX3_HUMANBioGRID, IntAct20211142 details
BIN1_HUMANZBTB3_HUMANIntAct20211142 details
BIN1_HUMANITA1_HUMANBioGRID, HPRD10094488 details
BIN1_HUMANITA3_HUMANBioGRID10094488 details
BIN1_HUMANCASP_HUMANBioGRID16169070 details
BIN1_HUMANPLD1_HUMANBioGRID10764771 details
BIN1_HUMANPLD2_HUMANBioGRID, HPRD10764771 details
BIN1_HUMANITA6_HUMANBioGRID, HPRD10094488 details
BIN1_HUMANCLIP1_HUMANBioGRID19004523 26506308 details
BIN1_HUMANA4_HUMANBioGRID21832049 details
BIN1_HUMANSOS2_HUMANBioGRID9182529 details
BIN1_HUMANAP2A1_HUMANBioGRID, HPRD9182529 9280305 details
BIN1_HUMANUBC_HUMANBioGRID17244534 details
BIN1_HUMANWASL_HUMANBioGRID25262827 details
BIN1_HUMANDYN2_HUMANBioGRID, HPRD15483625 25350771 details
BIN1_HUMANRAP1A_HUMANBioGRID, HPRD15207703 details
BIN1_HUMANE2F1_HUMANBioGRID25257171 30733337 details
BIN1_HUMANSYNE2_HUMANBioGRID26506308 details
BIN1_HUMANACTS_HUMANBioGRID26506308 details
BIN1_HUMANITCH_HUMANBioGRID26613292 28235806 details
BIN1_HUMANFHL2_HUMANBioGRID10906324 details
BIN1_HUMANACTG_HUMANBioGRID28893863 details
BIN1_HUMANP73_HUMANHPRD11709703 details
BIN1_HUMANATX2_HUMANHPRD16115810 details
BIN1_HUMANBIN2_HUMANBioGRID, IntAct, UniProt10903846 28514442 details
BIN1_HUMANKPYM_HUMANIntAct24606918 31413325 details
BIN1_HUMANAMPH_HUMANBioGRID, HPRD, IntAct28514442 31413325 9348539 details
BIN1_HUMANCAC1C_HUMANDIP20169111 details
BIN1_HUMANPIAS3_HUMANIntAct31413325 details
BIN1_HUMANPWP2A_HUMANIntAct31413325 details
BIN1_HUMANPARP1_HUMANIntAct31413325 details
BIN1_HUMANAGRA3_HUMANIntAct31413325 details
BIN1_HUMANRNB3L_HUMANIntAct31413325 details
BIN1_HUMANFHL1_HUMANIntAct31413325 details
BIN1_HUMANMTF2_HUMANIntAct31413325 details
BIN1_HUMANATF6A_HUMANIntAct31413325 details
BIN1_HUMANSMHD1_HUMANIntAct31413325 details
BIN1_HUMANWBP2_HUMANIntAct31413325 details
BIN1_HUMANHECD1_HUMANIntAct31413325 details
BIN1_HUMANZN451_HUMANIntAct31413325 details
BIN1_HUMANGAS6_HUMANIntAct31413325 details
BIN1_HUMANKS6C1_HUMANIntAct31413325 details
BIN1_HUMANGNL3_HUMANIntAct31413325 details
BIN1_HUMANSTXB1_HUMANIntAct31413325 details
BIN1_HUMANPAX6_HUMANIntAct31413325 details
BIN1_HUMANRAB24_HUMANIntAct31413325 details
BIN1_HUMANPEPL_HUMANIntAct31413325 details
BIN1_HUMANYETS2_HUMANIntAct31413325 details
BIN1_HUMANLRIF1_HUMANIntAct31413325 details
BIN1_HUMANPSA7_HUMANIntAct31413325 details
BIN1_HUMANPTPRD_HUMANIntAct31413325 details
BIN1_HUMANBCAT2_HUMANIntAct31413325 details
BIN1_HUMANRBP2_HUMANIntAct31413325 details
BIN1_HUMANRYR2_HUMANIntAct31413325 details
BIN1_HUMANRL8_HUMANIntAct31413325 details
BIN1_HUMANTSNAX_HUMANIntAct31413325 details
BIN1_HUMANUBC9_HUMANIntAct31413325 details
BIN1_HUMANMCAF2_HUMANIntAct31413325 details
BIN1_HUMANRANB3_HUMANIntAct31413325 details
BIN1_HUMANPIAS1_HUMANIntAct31413325 details
BIN1_HUMANSYNJ2_HUMANIntAct31413325 details
BIN1_HUMANSIAT9_HUMANIntAct31413325 details
BIN1_HUMANDPM1_HUMANIntAct31413325 details
BIN1_HUMANPIAS2_HUMANIntAct31413325 details
BIN1_HUMANZN251_HUMANIntAct31413325 details
BIN1_HUMANKS6A5_HUMANIntAct31413325 details
BIN1_HUMANZ518A_HUMANIntAct31413325 details
BIN1_HUMANFAK1_HUMANBioGRID12558988 details
BIN1_HUMANXRCC6_HUMANBioGRID17671430 details
BIN1_HUMANXRCC5_HUMANBioGRID17671430 details
BIN1_HUMANSYN1_HUMANBioGRID, HPRD10899172 details
BIN1_HUMANACK1_HUMANBioGRID19144635 details
BIN1_HUMANCLH1_HUMANBioGRID9195986 details
BIN1_HUMANAP2A2_HUMANBioGRID, HPRD10430869 9195986 details
BIN1_HUMANCALM1_HUMANBioGRID27093085 details
BIN1_HUMANCALM2_HUMANBioGRID27093085 details
BIN1_HUMANCALM3_HUMANBioGRID27093085 details
BIN1_HUMANEH1L1_HUMANBioGRID26833786 details
BIN1_HUMANRAB8A_HUMANBioGRID26833786 details
BIN1_HUMANRAB8B_HUMANBioGRID26833786 details
BIN1_HUMANCHM4B_HUMANBioGRID28806752 details
BIN1_HUMANCLUS_HUMANBioGRID25051234 details
BIN1_HUMANBECN1_HUMANBioGRID31211444 details
BIN1_HUMANFCG3A_HUMANBioGRID31211444 details
BIN1_HUMANFCG2A_HUMANBioGRID31211444 details
BIN1_HUMANPLK1_HUMANBioGRID31815296 details
BIN1_HUMANEF2_HUMANBioGRID31815296 details
BIN1_HUMANCDC73_HUMANBioGRID31815296 details
BIN1_HUMANIF2B1_HUMANBioGRID31815296 details
BIN1_HUMANBGAL_HUMANBioGRID31815296 details
BIN1_HUMANABL1_HUMANHPRD9356459 details
BIN1_HUMANSH3G2_HUMANHPRD9315708 details
BIN1_HUMANM4K3_HUMANHPRD11384986 details
BIN1_HUMANSYNJ1_HUMANHPRD9195986 9341169 details
BIN1_HUMANRIN2_HUMANHPRD12972505 details
BIN1_HUMANSHLB1_HUMANHPRD12456676 details
BIN1_HUMANASAP2_HUMANHPRD15483625 details